Felodipine
Chemical Name: 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid ethyl methyl ester
Purity: ≥98%
Biological Activity
Felodipine is a L-type Ca2+ channel blocker that is selective over N-, R-, P/Q- and T-type channels. Displays high vascular selectivity; lowers arterial blood pressure without altering cardiac contractility. Antihypertensive.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Vascular selectivity of felodipine: experimental pharmacology.
Ljung
J.Cardiovasc.Pharmacol., 1990;15:S11 -
Selectivities of dihydropyridine derivatives in blocking Ca2+ channel subtypes expressed in Xenopus oocytes.
Furukawa et al.
J.Pharmacol.Exp.Ther., 1999;291:464 -
Differential blocking action of dihydropyridine Ca2+ antagonists on a T-type Ca2+ channel (α1G) expressed in Xenopus oocytes.
Furukawa et al.
J.Cardiovasc.Pharmacol., 2005;45:241
Product Datasheets
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