Fenofibrate
Chemical Name: 2-[4-(4-Chlorobenzoyl)phenoxy]-2-methylpropanoic acid isopropyl ester
Purity: ≥99%
Biological Activity
Fenofibrate is a PPARα agonist; hypolipidemic. Attenuates insulin resistance and increases high-density lipoprotein-cholesterol in db/db mice.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Additive Renoprotection by Pioglitazone and Fenofibrate against Inflammatory, Oxidative and Apoptotic Manifestations of Cisplatin Nephrotoxicity: Modulation by PPARs.
Helmy M, Helmy M, El-Mas M
PLoS ONE, 2015;10(11):e0142303. -
The direct peroxisome proliferator-activated receptor target fasting-induced adipose factor (FIAF/PGAR/ANGPTL4) is present in blood plasma as a truncated protein that is increased by fenofi. treatment.
Mandard et al.
J.Biol.Chem., 2004;279:34411 -
PPARα agonist fenofi. improves diabetic nephropathy in db/db mice.
Park et al.
Kidney Int., 2006;69:1511 -
Pleiotropic actions of fenofi. on the heart.
Balakumar et al.
Pharmacol.Res., 2011;63:8
Product Datasheets
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Citations for Fenofibrate
The citations listed below are publications that use Tocris products. Selected citations for Fenofibrate include:
5 Citations: Showing 1 - 5
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Peroxisome Proliferator-Activated Receptor α Agonist and Its Target Nanog Cooperate to Induce Pluripotency.
Authors: Lee Et al.
J Clin Med 2018;7
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Additive Renoprotection by pioglit. and fenofi. against Inflammatory, Oxidative and Apoptotic Manifestations of cisp. Nephrotoxicity: Modulation by PPARs.
Authors: Helmy Et al.
PLoS One 2015;10:e0142303
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Modulators of hepatic lipoprotein metabolism identified in a search for small-molecule inducers of tribbles pseudokinase 1 expression.
Authors: Nagiec Et al.
J Pharmacol Exp Ther 2015;10:e0120295
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Palmitoylethanolamide stimulates phagocytosis of Escherichia coli K1 by macrophages and increases the resistance of mice against infections.
Authors: Redlich Et al.
PLoS One 2014;11:108
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5-Aminoimidazole-4-carboxyamide-ribonucleoside (AICAR)-stimulated hepatic expression of Cyp4a10, Cyp4a14, Cyp4a31, and other peroxisome proliferator-activated receptor α-responsive mouse genes is AICAR 5'-monophosphate-dependent and AMP-activated
Authors: Bumpus and Johnson
Invest Ophthalmol Vis Sci 2011;339:886
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