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FH 535

Catalog #: 4344
4 Citations Datasheet / COA / SDS

Discontinued Product

4344 has been discontinued.
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FH 535 | CAS No. 108409-83-2 | beta-Catenin Inhibitors
1 Image
Description: Inhibitor of Wnt/β-catenin signaling

Chemical Name: 2,5-Dichloro-N-(2-methyl-4-nitrophenyl)benzenesulfonamide

Purity: ≥99%

Product Details
Citations (4)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

FH 535 is an inhibitor of Wnt/β-catenin signaling and dual antagonist of PPARγ/δ activity. Suppresses β-catenin/Tcf-mediated transcription; inhibits β-catenin and GRIP1 recruitment to PPARγ and δ. Exhibits antiproliferative effects in transformed colon, lung and liver cancer cell lines.

Technical Data

M.Wt:
361.2
Formula:
C13H10Cl2N2O4S
Solubility:
Soluble to 75 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
108409-83-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Exosomes Mediate Mobilization of Autocrine Wnt10b to Promote Axonal Regeneration in the Injured CNS
    NG Tassew, J Charish, AP Shabanzade, V Luga, H Harada, N Farhani, P D'Onofrio, B Choi, A Ellabban, PEB Nickerson, VA Wallace, PD Koeberle, JL Wrana, PP Monnier
    Cell Rep, 2017;20(1):99-111.
  2. Role of retinal pigment epithelial cell beta-catenin signaling in experimental proliferative vitreoretinopathy.
    Umazume K, Tsukahara R, Liu L, Fernandez de Castro J, McDonald K, Kaplan H, Tamiya S
    Am J Pathol, 2014;184(5):1419-28.
  3. A small-molecule inhibitor of Tcf/β-catenin signaling down-regulates PPARγ and PPARδ activities.
    Handeli and Simon
    Mol.Cancer Ther., 2008;7:521

Product Datasheets

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Citations for FH 535

The citations listed below are publications that use Tocris products. Selected citations for FH 535 include:

4 Citations: Showing 1 - 4

  1. The antimicrobial peptide S100A8/A9 produced by airway epithelium functions as a potent and direct regulator of macrophage phenotype and function.
    Authors: Stefan Et al.
    Eur Respir J  2022;59
  2. Insulin-like growth factor binding protein 4 inhibits proliferation of bone marrow mesenchymal stem cells and enhances growth of neurospheres derived from the stem cells.
    Authors: Qunyuan Et al.
    Cell Biochem Funct  2018;36:331-341
  3. Live cell screening platform identifies PPARδ as a regulator of cardiomyocyte proliferation and cardiac repair.
    Authors: Lan Et al.
    Cell Res  2017;27:1002-1019
  4. Metabolic origins of spatial organization in the tumor microenvironment.
    Authors: Craig B Et al.
    Proc Natl Acad Sci U S A  2017;114:2934-2939

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