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FIN 56

Catalog #: 6280
1 Citation Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6280/25
6280/5
FIN 56 | CAS No. 1083162-61-1 | Ferroptosis Activators
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Description: Ferroptosis activator

Chemical Name: N2,N7-Dicyclohexyl-9-(hydroxyimino)-9H-fluorene-2,7-disulfonamide

Purity: ≥98%

Product Details
Citations (1)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

FIN 56 is a bifunctional inducer of ferroptosis in vitro. Activates squalene synthase (SQS) leading to coenzyme Q10 depletion. Also induces degradation of glutathione peroxidase 4 (GPX4), via acetyl-CoA carboxylase (ACC).

Technical Data

M.Wt:
517.66
Formula:
C25H31N3O5S2
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1083162-61-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Chemical genetics: Unraveling cell death mysteries.
    Cotto-Rios and Gavathiotis
    Nat.Chem.Biol., 2016;12:470
  2. Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis.
    Shimada et al.
    Nat.Chem.Biol., 2016;12:497

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citation for FIN 56

The citations listed below are publications that use Tocris products. Selected citations for FIN 56 include:

1 Citation: Showing 1 - 1

  1. Human DECR1 is an androgen-repressed survival factor that regulates PUFA oxidation to protect prostate tumor cells from ferroptosis.
    Authors: Jeff Et al.
    Elife  2020;9

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