Flumazenil
Chemical Name: 8-Fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid, ethyl ester
Purity: ≥99%
Biological Activity
Flumazenil is a benzodiazepine antagonist, non-selective for α1, α2, α3 or α5-containing GABAA receptors. Centrally active upon systemic administration in vivo. Also inhibits repressor element-1 silencing transcription factor (REST) by targeting degradation.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
Regional differences in the inhibition of mouse in vivo [3H]Ro 15-1788 binding reflect selectivity for α1 versus α2 and α3 subunit-containing GABAA receptors.
Atack et al.
Neuropsychopharmacology, 1999;20:255 -
New insights into the mechanism of action of hypnotics.
Dobl
J.Psychopharmacol., 1999;13:S11 -
Electrophysiological studies on the specific benzodiazepine antagonist Ro 15-1788.
Polc et al.
Naunyn Schmiedebergs Arch.Pharmacol., 1981;316:317
Product Datasheets
Reconstitution Calculator
Molarity Calculator
Citations for Flumazenil
The citations listed below are publications that use Tocris products. Selected citations for Flumazenil include:
7 Citations: Showing 1 - 7
-
Structure of a human synaptic GABAA receptor.
Authors: Zhu
Nature 2018;559(7712):67
-
Local GABAA receptor mediated suppression of DA release within the nucleus accumbens.
Authors: Brodnik Et al.
ACS Chem Neurosci 2018;17:1978
-
Gene expression alterations in the cerebellum and granule neurons of Cstb(-/-) mouse are associated with early synaptic changes and inflammation.
Authors: Joensuu Et al.
PLoS One 2014;9:e89321
-
SB-205384 is a positive allosteric modulator of recombinant GABAA receptors containing rat α3, α5, or α6 subunit subtypes coexpressed with β3 and γ2 subunits.
Authors: Heidelberg Et al.
J Pharmacol Exp Ther 2013;347:235
-
An anxiolytic-like effect of hyperbaric oxygen in the mouse light/dark exploration test.
Authors: Carlile Et al.
Life Sci 2012;90:267
-
Removal of GABA(A) receptor γ2 subunits from parvalbumin neurons causes wide-ranging behavioral alterations.
Authors: Leppä Et al.
PLoS One 2011;6:e24159
-
Ro 15-4513 Antagonizes Alcohol-Induced Sedation in Mice Through αβγ2-type GABA(A) Receptors.
Authors: Linden Et al.
Front Neurosci 2011;5:3
FAQs
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQsReviews for Flumazenil
There are currently no reviews for this product. Be the first to review Flumazenil and earn rewards!
Have you used Flumazenil?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
