Fumagillin
Chemical Name: (2E,4E,6E,8E)-Mono[(3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-1-oxaspiro[2.5]oct-6-yl] 2,4,6,8-decatetraenedioic acid ester
Biological Activity
Fumagillin is an antibiotic and antiangiogenic agent; covalently binds and inhibits methionine aminopeptidase-2. Inhibits endothelial cell proliferation in vitro and tumor-induced angiogenesis in vivo. Also inhibits tumor growth in mice.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Development and validation of an automated high-throughput system for zebrafish in vivo screenings.
Letamendia A, Quevedo C, Ibarbia I
PLoS ONE, 2012;7(5):e36690. -
The anti-angiogenic agent fumagillin covalently modifies a conserved active-site histidine in the Escherichia coli methionine aminopeptidase.
Lowther et al.
Proc.Natl.Acad.Sci.U.S.A., 1998;95:12153 -
Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth.
Ingber et al.
Nature, 1990;348:555 -
Cytochemical evidence for RNA synthesis inhibition by fumagillin.
Jaronski
J.Antibiot., 1972;25:327 -
A re-evaluation of fumagillin selectivity towards endothelial cells.
Rodriguez-Nieto et al.
Anticancer Res., 2001;21:3457
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Citation for Fumagillin
The citations listed below are publications that use Tocris products. Selected citations for Fumagillin include:
1 Citation: Showing 1 - 1
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A novel angiopoietin-derived peptide displays anti-angiogenic activity and inhibits tumour-induced and retinal neovascularization.
Authors: Palmer Et al.
Br J Pharmacol 2012;165:1891
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