Galanthamine hydrobromide
Chemical Name: 4a,5,9,10,11,12-Hexahydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-ol hydrobromide
Purity: ≥98%
Biological Activity
Galanthamine hydrobromide is a long-acting, centrally active acetylcholinesterase inhibitor (IC50 = 410 nM) and allosteric potentiator at neuronal nicotinic ACh receptors. Prevents β-amyloid-induced apoptosis in SH-SY5Y and bovine chromaffin cells. Long-term administration reduces amyloid precursor protein deposition and neurodegeneration in a mouse model of Alzheimer's disease.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
Galantamine prevents apoptosis induced by β-amyloid and thapsigargin: involvement of nicotinic acetycholine receptors.
Arias et al.
Neuropharmacology, 2004;46:103 -
The pharmacology of galanthamine and its analogues.
Harvey
Pharmacol.Ther., 1995;68:113 -
Galanthamine, an acetylcholinesterase inhibitor: a time course of the effects on performance and neurochemical parameters in mice.
Sweeney et al.
Pharmacol.Biochem.Behav., 1989;34:129 -
Galantamine is an allosterically potentiating ligand of neuronal nicotinic but not of muscarinic acetylcholine receptors.
Samochocki et al.
J.Pharmacol.Exp.Ther., 2003;305:1024 -
Nerve growth factor and galant. ameliorate early signs of neurodegeneration in anti-nerve growth factor mice.
Capsoni et al.
Proc.Natl.Acad.Sci.U.S.A., 2002;99:12432
Product Datasheets
Reconstitution Calculator
Molarity Calculator
Citation for Galanthamine hydrobromide
The citations listed below are publications that use Tocris products. Selected citations for Galanthamine hydrobromide include:
1 Citation: Showing 1 - 1
-
Galantamine improves olfactory learning in the Ts65Dn mouse model of Down syndrome.
Authors: Souza Et al.
Sci Rep 2012;1:137
FAQs
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQsReviews for Galanthamine hydrobromide
There are currently no reviews for this product. Be the first to review Galanthamine hydrobromide and earn rewards!
Have you used Galanthamine hydrobromide?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image