GBR 12783 dihydrochloride
Chemical Name: 1-(2-Diphenylmethoxyethyl)-4-(3-phenyl-2-propenyl)-piperazine dihydrochloride
Purity: ≥99%
Biological Activity
GBR 12783 dihydrochloride is a very potent and selective inhibitor of dopamine uptake (IC50 for inhibition of [3H]-dopamine uptake in rat striatal synaptosomes is 1.8 nM).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
GBR 12783, a potent and selective inhibitor of DA uptake: biochemical studies in vivo and ex vivo.
Bonnet and Constentin
Eur.J.Pharmacol., 1986;121:199 -
Evidence for the sequential formation of two complexes between an uptake inhibitor, GBR 12783 [1-[2-(diphenylmethoxy)ethyl]-4-(3-phenyl-2-propenyl)piperazine], and the neuronal transporter of DA.
Do-Rego et al.
J.Neurochem., 1999;72:396 -
Cloning, pharmacological characterization and chromosome assignment of the human DA transporter.
Giros et al.
Mol.Pharmacol., 1992;42:383 -
In vivo labelling of the neuronal DA uptake complex in the mouse striatum by [3H]GBR 12783.
Vaugeois et al.
Eur.J.Pharmacol., 1992;210:77
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Citations for GBR 12783 dihydrochloride
The citations listed below are publications that use Tocris products. Selected citations for GBR 12783 dihydrochloride include:
4 Citations: Showing 1 - 4
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Cocaine Inhibition of Synaptic Transmission in the Ventral Pallidum Is Pathway-Specific and Mediated by Serotonin.
Authors: Matsui and Alvarez
Cell Rep 2018;23(13):3852
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MPP(+) -dependent inhibition of Ih reduces spontaneous activity and enhances EPSP summation in nigral DA neurons.
Authors: Masi Et al.
Br J Pharmacol 2013;169:130
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Presynaptic CB(1) cannabinoid receptors control frontocortical serotonin and glutamate release--species differences.
Authors: Ferreira Et al.
J Pharmacol Exp Ther 2012;61:219
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A novel mechanism of cocaine to enhance DA d2-like receptor mediated neurochemical and behavioral effects. An in vivo and in vitro study.
Authors: Ferraro Et al.
Neuropsychopharmacology 2012;37:1856
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