GKA 50
Chemical Name: 6-[[3-[(1S)-2-Methoxy-1-methylethoxy]-5-[(1S)-1-methyl-2-phenylethoxy]benzoyl]amino-3-pyridinecarboxylic acid
Purity: ≥98%
Biological Activity
GKA 50 is a potent glucokinase activator (EC50 = 33 nM). Significantly reduces plasma glucose levels in diabetic rats; stimulates insulin release from mouse islets of Langerhans.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Predictive blood glucose lowering efficacy by Glucokinase activators in high fat fed female Zucker rats.
Coope et al.
Br.J.Pharmacol., 2006;149:328 -
Glucokinase activators: molecular tools for studying the physiology of Ins-Secr.g cells.
Johnson et al.
Biochem.Soc.Trans., 2007;35:1208
Product Datasheets
Reconstitution Calculator
Molarity Calculator
FAQs
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQsReviews for GKA 50
There are currently no reviews for this product. Be the first to review GKA 50 and earn rewards!
Have you used GKA 50?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
