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Glibenclamide

Catalog #: 0911
15 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
0911/100
Glibenclamide | CAS No. 10238-21-8 | Inward Rectifier Potassium Channel Blockers
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Description: Kir6 (KATP) channel blocker
Alternative Names: Glyburide

Chemical Name: 5-Chloro-N-[2-[4-[[[(Cylcohexylamino)carbonyl]amino]sulphonyl]phenyl]ethyl]-2-methoxybenzamide

Purity: ≥99%

Product Details
Citations (15)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Glibenclamide is an ATP-dependent K+ channel (Kir6, KATP) and CFTR Cl- channel blocker. Inhibits Kir6 currents in the pancreas, causing an increase in intracellular Ca2+ and insulin secretion. Inhibits recombinant CFTR Cl- channels with an IC50 of 20 μM.

Technical Data

M.Wt:
494
Formula:
C23H28ClN3O5S
Solubility:
Soluble to 100 mM in DMSO and to 5 mM in ethanol
Purity:
≥99%
Storage:
Store at RT
CAS No:
10238-21-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Nociceptin induces hypophagia in the perifornical and lateral hypothalamic area.
    Parsons, Matthew, Burt, Julia, Cranford, Amanda, Alberto, Christia, Zipperlen, Katrin, Hirasawa, Michiru
    PLoS ONE, 2012;7(9):e45350.
  2. CLEC5A is critical for dengue virus-induced inflammasome activation in human macrophages.
    Wu M, Chen S, Yang A, Lin W, Lin Y, Chen N, Tsai I, Li L, Hsieh S
    Blood, 2013;121(1):95-106.
  3. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
    Fox JT, Sakamuru S, Huang R
    Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
  4. Glibenclamide: a review.
    Brogden et al.
    Drugs, 1979;18:329
  5. Potassium channel modulators: scientific applications and therapeutic promise.
    Robertson et al.
    J.Med.Chem., 1990;33:1529
  6. Effect of ATP-sensitive K+ channel regulators on cystic fibrosis transmembrane conductance regulator chloride channels.
    Sheppard and Welsh
    J.Gen.Physiol., 1992;100:573

Product Datasheets

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Citations for Glibenclamide

The citations listed below are publications that use Tocris products. Selected citations for Glibenclamide include:

15 Citations: Showing 1 - 10

  1. TRPM4 Conductances in Thalamic Reticular Nucleus Neurons Generate Persistent Firing during Slow Oscillations
    Authors: O'Malley Et al.
    J Neurosci  2020;40:4813
  2. Antidiarrhoeal, antisecretory and antispasmodic activities of Matricaria chamomilla are mediated predominantly through K(+)-channels activation.
    Authors: Mehmood Et al.
    Neuroscience  2015;15:75
  3. Dissecting out the complex Ca2+-mediated phenylephrine-induced contractions of mouse aortic segments.
    Authors: Fransen Et al.
    Biomed Res Int  2015;10:e0121634
  4. Regulation of neurons in the dorsal motor nucleus of the vagus by SIRT1.
    Authors: Jiang and Zsombok
    Front Neurosci  2014;7:270
  5. Characterization of imidazoline receptors in blood vessels for the development of antihypertensive agents.
    Authors: Chen Et al.
    J Pharmacol Exp Ther  2014;2014:182846
  6. Acute SimV. inhibits K ATP channels of porcine coronary artery myocytes.
    Authors: Seto Et al.
    J Neurophysiol  2013;8:e66404
  7. Effect of the ginsenoside Rb1 on the spontaneous contraction of intestinal smooth muscle in mice.
    Authors: Xu
    World J Gastroenterol  2012;18:5462
  8. Activation of peripheral δ-opioid receptors leads to anti-hyperalgesic responses in the masseter muscle of male and female rats.
    Authors: Saloman Et al.
    PLoS One  2011;190:379
  9. The acute antinociceptive effect of HBO2 is mediated by a NO-cyclic GMP-PKG-KATP channel pathway in mice.
    Authors: Quock Et al.
    Brain Res  2011;1368:102
  10. Role of perivascular adipose tissue-derived methyl palmitate in vascular tone regulation and pathogenesis of hypertension.
    Authors: Lee Et al.
    Circulation  2011;124:1160

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