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Glycine

Catalog #: 0219
4 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
0219/1G
Glycine | CAS No. 56-40-6 | Additional NMDA Receptor Compounds
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Description: Endogenous potentiator of NMDA receptors

Chemical Name: Aminoethanoic acid

Product Details
Citations (4)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

One of the major inhibitory neurotransmitters in the mammalian CNS, predominantly active in the spinal cord and brain stem. Also acts as a modulator of excitatory amino acid transmission mediated by NMDA receptors.

Technical Data

M.Wt:
75.07
Formula:
C2H5NO2
Solubility:
Soluble to 100 mM in water
Storage:
Store at RT
CAS No:
56-40-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Olanzapine: preclinical and clinical profiles of a novel antipsychotic agent.
    Tollefson and Taylor
    CNS Drug Reviews, 2000;6:303
  2. Glycine receptors: heterogeneous and widespread in the mammalian brain.
    Betz
    Trends Neurosci., 1991;14:458
  3. The inhibitory glycine receptor: architecture, synaptic localization and molecular pathology of a postsynaptic ion-channel complex.
    Kuhse et al.
    Curr.Opin.Neurobiol., 1995;5:318
  4. Glycine potentiates the NMDA response in cultured mouse brain neurons.
    Johnson and Ascher
    Nature, 1987;325:529
  5. The NMDA receptor, its channel and its modulation by glycine.
    Ascher and Johnson
    The NMDA Receptor (2nd edition). Eds. G.L.Collingr, 1989;:109

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Citations for Glycine

The citations listed below are publications that use Tocris products. Selected citations for Glycine include:

4 Citations: Showing 1 - 4

  1. Neuronal Activity and Intracellular Calcium Levels Regulate Intracellular Transport of Newly Synthesized AMPAR.
    Authors: Hangen Et al.
    Cell Rep  2018;24:1001
  2. Selective inhibition of KCC2 leads to hyperexcitability and epileptiform discharges in hippocampal slices and in vivo.
    Authors: Sivakumaran Et al.
    Front Cell Neurosci  2015;35:8291
  3. The integrity of the glycine co-agonist binding site of N-MthD.-aspartate receptors is a functional quality control checkpoint for cell surface delivery.
    Authors: Kenny Et al.
    J Biol Chem  2009;284:324
  4. Mechanisms of microglia-mediated neurotoxicity in a new model of the stroke penumbra.
    Authors: Kaushal and Schlichter
    J Neurosci  2008;28:2221

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