GNF 5
Chemical Name: N-(2-Hydroxyethyl)-3-[6-[[4-(trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]benzamide
Purity: ≥98%
Biological Activity
GNF 5 is a selective, non-ATP competitive allosteric inhibitor of Bcr-Abl (IC50 = 220 nM for wild-type Abl). Binds the myristate-binding site of Abl. Acts in combination with nilotinib to inhibit T315I Bcr-Abl in vitro and in vivo. Analog of GNF 2 (Cat. No. 4399). GNF 5 decreases mitochondrial function in lung cancer cells.External Portal Information
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of GNF 5 is reviewed on the chemical probes website.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors.
Zhang et al.
Nature, 2010;463:501 -
Allosteric interactions between the myristate- and ATP-site of the Abl kinase.
Iacob et al.
PLoS One, 2011;6:e15929 -
Expanding the diversity of allosteric Bcr-Abl inhibitors.
Deng et al.
J.Med.Chem., 2010;53:6934
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