GPBAR-A
Chemical Name: 4-[[3,5-Bis(trifluoromethyl)phenyl]methyl]-6-(2-fluorophenyl)-4,5-dihydro-pyrido[3,2-f]-1,4-oxazepin-3(2H)-one
Purity: ≥98%
Biological Activity
GPBAR-A is a gPBA receptor agonist. Upregulates GLP-1 secretion from intestinal cultures. Increases MQAE-fluorescence suggesting a decrease in intracellular chloride concentration in gallbladder epithelial cells.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Molecular mechanisms underlying bile acid-stimulated glucagon-like peptide-1 secretion.
Parker et al.
Br.J.Pharmacol., 2012;165:414 -
The membrane-bound bile acid receptor TGR5 is localized in the epithelium of human gallbladders.
Keitel et al.
Hepatology, 2009;50:861
Product Datasheets
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Citations for GPBAR-A
The citations listed below are publications that use Tocris products. Selected citations for GPBAR-A include:
2 Citations: Showing 1 - 2
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A turquoise fluorescence lifetime-based biosensor for quantitative imaging of intracellular calcium.
Authors: Bas Et al.
Nat Commun 2021;12:7159
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Bile acid effects are mediated by ATP release and purinergic signalling in exocrine pancreatic cells.
Authors: Kowal Et al.
Stem Cells Transl Med 2015;13:28
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