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GPP 78 hydrochloride

Catalog #: 4835
1 Citation Datasheet / COA / SDS

Discontinued Product

4835 has been discontinued.
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GPP 78 hydrochloride | NAMPT Inhibitors
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Description: NAMPT inhibitor; also induces autophagy

Chemical Name: N-[1,1'-Biphenyl]-2-yl-4-(3-pyridinyl)-1H,1,2,3-triazole-1-octanamide hydrochloride

Purity: ≥98%

Product Details
Citations (1)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

GPP 78 hydrochloride is an inhibitor of nicotinamide phosphoribosyltransferase (NAMPT); potently depletes NAD levels and exhibits cytotoxicity in vitro (IC50 values are 3.0 and 3.8 nM respectively). Also shown to induce autophagy in neuroblastoma cells.

Technical Data

M.Wt:
476.01
Formula:
C27H29N5O.HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citation for GPP 78 hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for GPP 78 hydrochloride include:

1 Citation: Showing 1 - 1

  1. PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma.
    Authors: Fons Et al.
    Nat Commun  2019;10:3790

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