GRASP1 Antibody

Catalog #: PPS052 Datasheet / COA / SDS

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PPS052

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GRASP1 Antibody Summary

Species Reactivity

Human, Mouse, Rat, Bovine, Canine

Specificity

This antibody is specific for the 95 kDa GRASP in Western blots of rat cerebellar lysates.

Source

Polyclonal Rabbit IgG

Purification

Antigen Affinity-purified

Immunogen

Peptide corresponding to amino acid residues from the C‑terminal region of rat GRASP, conjugated to keyhole limpet hemocyanin (KLH)

Formulation

100 μL in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50% glycerol.

Label

Unconjugated

Applications

Recommended Concentration

Sample

Western Blot

1:1000 dilution

See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Western Blot

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Detection of GRASP by Western Blot. Western blot of rat cerebellar lysate showing the specific immunolabeling of the approximately 95 kDa GRASP protein.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

For long-term storage, ≤‑20° C is recommended. Product is stable at ≤ ‑20° C for at least 1 year.

Background: GRASP1

PDZ domain-containing proteins, such as PSD-95 and GRIP are thought to play key roles in glutamate receptor plasticity. GRIP-associated proteins (GRASPs) that bind to distinct PDZ domains within GRIP also play key roles in regulation of glutamate receptor function. GRASP-1 is a neuronal rasGEF associated with GRIP and AMPA receptors in vivo. Recent work suggests that GRASP-1 may regulate neuronal ras signaling and contribute to the regulation of AMPA receptor distribution by NMDA receptor activity.

References