GRI 977143
Chemical Name: 2-[[3-(1,3-dioxo-1H-benz[de]isoquinolin-2(3H)-yl)propyl]thio]benzoic acid
Purity: ≥98%
Biological Activity
GRI 977143 is a selective lysophosphatidic acid 2 (LPA2) receptor non-lipid agonist (EC50 = 3.3 μM). Does not activate other LPA GPCRs at concentrations up to 10 μM. Antiapoptotic; inhibits activation of caspases 3, 7, 8 and 9, Bax translocation and PARP-1 cleavage. Activates ERK1/2 survival pathway.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Virtual screening for LPA2-specific agonists identifies a nonlipid compound with antiapoptotic actions.
Kiss et al.
Mol.Pharmacol., 2012;82:1162 -
Mitigation of radiation injury by selective stimulation of the LPA(2) receptor.
Kiss et al.
Biochim.Biophys.Acta, 2013;1831:117
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