Home / NADPH Oxidase Inhibitors / GSK 2795039

GSK 2795039

Catalog #: 6848 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6848/5
6848/25
GSK 2795039 | CAS No. 1415925-18-6 | NADPH Oxidase Inhibitors
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Description: NADPH oxidase 2 (NOX2) inhibitor

Chemical Name: N-[3-(2,3-Dihydro-1-methyl-1H-indol-6-yl)-1-(1-methylethyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1-methyl-1H-pyrazole-3-sulfonamide

Purity: ≥98%

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Biological Activity

GSK 2795039 is a NADPH oxidase 2 (NOX2) inhibitor (pIC50 value is 5.5 to 6.5, depending on assay performed), which displays selectivity for NOX2 other NOX isoforms, xanthine oxidase and eNOS. GSK 2795039 inhibits reactive oxygen species (ROS) in cellular assays, and displays efficacy in rodent models of paw inflammation and acute pancreatitis.

Technical Data

M.Wt:
450.56
Formula:
C23H26N6O2S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1415925-18-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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