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GSK 319347A

Catalog #: 5672
1 Citation Datasheet / COA / SDS
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GSK 319347A | CAS No. 862812-98-4 | IkB Kinase Inhibitors
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Description: Potent and selective IKKε inhibitor

Chemical Name: 5-(5,6-Dimethoxy-1H-benzimidazol-1-yl)-3-[[2-(methylsulfonyl)phenyl]methoxy]-2-thiophenecarbonitrile

Purity: ≥98%

Product Details
Citations (1)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

GSK 319347A is a potent and selective IKKε inhibitor (pIC50 = 7.4). Exhibits >100-fold selectivity for IKKε over IKKα IKKβ, and a range of other kinases.

Technical Data

M.Wt:
469.53
Formula:
C22H19N3O5S2
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
862812-98-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. 5-(1H-Benzimidazol-1-yl)-3-alkoxy-2-thiophenecarbonitriles as potent, selective, inhibitors of IKK-ε kinase.
    Bamborough et al.
    Bioorg.Med.Chem.Lett., 2006;16:6236

Product Datasheets

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Citation for GSK 319347A

The citations listed below are publications that use Tocris products. Selected citations for GSK 319347A include:

1 Citation: Showing 1 - 1

  1. The PI3K/mTOR inhibitor Gedatolisib eliminates dormant breast cancer cells in organotypic culture, but fails to prevent metastasis in preclinical settings.
    Authors: Mina J Et al.
    Mol Oncol  2022;16:130-147

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