GSK 923295A
Chemical Name: 3-Chloro-N-[(1S)-2-[[2-(dimethylamino)acetyl]amino]-1-[[4-[8-[(1S)-1-hydroxyethyl]imidazo[1,2-a]pyridin-2-yl]phenyl]methyl]ethyl]-4-(1-methylethoxy)benzamide
Purity: ≥97%
Biological Activity
GSK 923295A is a potent and selective centromere associated protein E (CENP-E) allosteric inhibitor (IC50 = 22 nM); does not compete with ATP. Exhibits selectivity over a panel of other kinesins (<25% inhibition at 50 μM). Inhibits tumor cell growth in vitro. Induces mitotic arrest and regression of human tumor xenografts in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Antitumor activity of an allosteric inhibitor of centromere-associated protein-E.
Wood et al.
Proc.Natl.Acad.Sci.U.S.A., 2010;107:5839 -
Discovery of the first potent and selective inhibitor of centromere-associated protein E: GSK923295.
Qian et al.
ACS Med.Chem.Lett., 2010;1:30
Product Datasheets
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