Home / Histone Demethylase Inhibitors / GSK LSD 1 dihydrochloride

GSK LSD 1 dihydrochloride

Catalog #: 5361
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GSK LSD 1 dihydrochloride | CAS No. 2102933-95-7 | Histone Demethylase Inhibitors
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Description: Potent and selective LSD1 inhibitor

Chemical Name: rel-N-[(1R,2S)-2-Phenylcyclopropyl]-4-piperidinamine dihydrochloride

Purity: ≥98%

Product Details
Citations (1)
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Biological Activity Technical Data Additional Information Product Datasheets Calculators

Biological Activity

GSK LSD 1 dihydrochloride is a potent and selective lysine specific demethylase 1 (LSD1) inhibitor (IC50 = 16 nM). Exhibits >1000-fold selectivity for LSD1 over closely related enzymes including LSD2, MAO-1 and MAO-B. Inhibits cancer cell line growth in vitro.

Technical Data

M.Wt:
289.24
Formula:
C14H20N2.2HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
2102933-95-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the GSK LSD 1 probe summary on the SGC website.

Product Datasheets

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Citation for GSK LSD 1 dihydrochloride

The citations listed below are publications that use Tocris products. Selected citations for GSK LSD 1 dihydrochloride include:

1 Citation: Showing 1 - 1

  1. Targeting histone demethylase LSD1 for treatment of deficits in autism mouse models.
    Authors: Ping Et al.
    Mol Psychiatry  2022;27:3355-3366

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