GT 949
Chemical Name: 3-((4-Cyclohexylpiperazin-1-yl)(1-phenethyl-1H-tetrazol-5-yl)methyl)-6-methoxyquinolin-2(1H)-one
Purity: ≥98%
Biological Activity
GT 949 is a potent and selective EAAT2 positive allosteric modulator (EC50 = 0.26 nM). Enhances the glutamate translocation rate, with no effect on substrate interaction. Enhances glutamate uptake by cultured astrocytes by approximately 58%. Exhibits no significant effect on DAT, SERT and NET or NMDA receptors. Neuroprotective in an in vitro model of excitotoxicity.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Identification of novel allosteric modulators of glutamate transporter EAAT2.
Kortagere et al.
ACS Chem Neurosci., 2018;9:522 -
Novel Positive Allosteric Modulators of Glutamate Transport Have Neuroprotective Properties in an in Vitro Excitotoxic Model.
Falcucci et al.
ACS Chem.Neurosci., 2019;10:3437
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Citation for GT 949
The citations listed below are publications that use Tocris products. Selected citations for GT 949 include:
1 Citation: Showing 1 - 1
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M�ller Glial Cells Participate in Retinal Waves via Glutamate Transporters and AMPA Receptors.
Authors: Zhang Et al.
Cell Rep 2019;27:2871
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