GW 583340 dihydrochloride
Chemical Name: N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[2-[[[2-(methylsulfonyl)ethyl]amino]methyl]-4-thiazolyl]-4-quinazolinamine dihydrochloride
Purity: ≥97%
Biological Activity
GW 583340 dihydrochloride is a potent dual EGFR/ErbB2 tyrosine kinase inhibitor (IC50 values are 0.01 and 0.014 μM respectively). Selectively inhibits growth of human tumor cells overexpressing EGFR and ErbB2 (IC50 values are 0.11 μM for inhibition of HN5, N87 and BT474 tumor cell lines vs. > 30 μM for inhibition of non-tumor cell line HFF). Inhibits tumor growth in vivo by ~ 80% in a murine xenograft model following oral administration.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
-
Discovery and biological evaluation of potent dual ErbB-2/EGFR tyrosine kinase inhibitors: 6-thiazolylquinazolines.
Gaul et al.
Bioorg.Med.Chem.Lett., 2003;13:637
Product Datasheets
Reconstitution Calculator
Molarity Calculator
Citation for GW 583340 dihydrochloride
The citations listed below are publications that use Tocris products. Selected citations for GW 583340 dihydrochloride include:
1 Citation: Showing 1 - 1
-
GW583340 and GW2974, human EGFR and HER-2 inhibitors, reverse ABCG2- and ABCB1-mediated drug resistance.
Authors: Sodani Et al.
Biochem Pharmacol 2012;83:1613
FAQs
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQsReviews for GW 583340 dihydrochloride
There are currently no reviews for this product. Be the first to review GW 583340 dihydrochloride and earn rewards!
Have you used GW 583340 dihydrochloride?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
