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GYKI 47261 dihydrochloride

Catalog #: 3099 Datasheet / COA / SDS

Discontinued Product

3099 has been discontinued.
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GYKI 47261 dihydrochloride | CAS No. 1217049-32-5 | AMPA Receptor Antagonists
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Description: Non-competitive AMPA antagonist

Chemical Name: 4-(8-Chloro-2-methyl-11H-imidazo[1,2-c][2,3]benzodiazepin-6-benzeneamine dihydrochloride

Purity: ≥99%

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Biological Activity

GYKI 47261 dihydrochloride is a non-competitive AMPA receptor antagonist (IC50 = 2.5 μM). Displays broad spectrum anticonvulsive activity and neuroprotective effects in vivo.

Technical Data

M.Wt:
395.71
Formula:
C18H15ClN4.2HCl
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
1217049-32-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. New non competitive AMPA antagonists.
    Abraham et al.
    Bioorg.Med.Chem., 2000;8:2127
  2. Combined blockade of AMPA and NMDA glutamate receptors reduces levodopa-induced motor complications in animal models of PD.
    Bibbiani et al.
    Exp.Neurol., 2005;196:422
  3. Research on new AMPA antagonists of 2,3-benzodiazepine type.
    Solyo
    Pharmazie, 2001;25:S62

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