H-7 dihydrochloride
Chemical Name: (±)-1-(5-Isoquinolinesulphonyl)-2-methylpiperazine dihydrochloride
Purity: ≥99%
Biological Activity
H-7 dihydrochloride is a protein kinase inhibitor (IC50 values for inhibition of PKA, PKG, PKC and myosin light chain kinase are 3.0, 5.8, 6.0 and 97.0 μM, respectively. H-7 shows antiviral activity against influenza A (IC50 = 10 μM) in vitro. H-7 also inhibits interleukin-stimulated secretion of IgM and blocks PMA-stimulated interleukin 1β production.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C.
Hidaka et al.
Biochemistry, 1984;23:5036 -
The structure and biological activities of the widely used protein kinase inhibitor, H7, differ depending on the commercial source.
Quick et al.
Biochem.Biophys.Res.Commun., 1992;187:657 -
Effect of the kinase inhibitor, H-7, on stress, crossbridge phosphorylation, muscle shortening and inositol phosphate production in rabbit arteries.
Ratz et al.
J.Pharmacol.Exp.Ther., 1990;252:253
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Citations for H-7 dihydrochloride
The citations listed below are publications that use Tocris products. Selected citations for H-7 dihydrochloride include:
4 Citations: Showing 1 - 4
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TRPV4 Blockade Preserves the Blood-Brain Barrier by Inhibiting Stress Fiber Formation in a Rat Model of Intracerebral Hemorrhage.
Authors: Zhao Et al.
Front Mol Neurosci 2018;11:97
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Enzymatic activity of CaMKII is not required for its interaction with the glutamate receptor subunit GluN2B.
Authors: Barcomb Et al.
Front Mol Neurosci 2013;84:834
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Cyclin-dependent kinase 2 phosphorylates s/t-p sites in the hepadnavirus core protein C-terminal domain and is incorporated into viral capsids.
Authors: Ludgate Et al.
J Virol 2012;86:12237
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A role for protein phosphatases 1, 2A, and 2B in cerebellar long-term potentiation.
Authors: Belmeguenai and Hansel
Mol Pharmacol 2005;25:10768
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