H2DCFDA
Chemical Name: 2-[3,6-Bis(acetyloxy)-2,7-dichloro-9H-xanthen-9-yl]benzoic acid
Purity: ≥95%
Biological Activity
H2DCFDA is a fluorescent ROS indicator; becomes fluorescent when oxidized. Excitation wavelength ~490 nm, emission ~520 nm. Cell permeable.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Sigma-2 receptors play a role in cellular metabolism: stimulation of glycolytic hallmarks by CM764 in human SK-N-SH neuroblastoma.
Nicholson et al.
J.Pharmacol.Exp.Ther., 2013;356:232 -
ROS-induced JNK and p38 signaling is required for unpaired cytokine activation during drosophila regeneration.
Santabárbara-Ruiz et al.
PLoS Genet., 2015;11:e1005595
Product Datasheets
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Citations for H2DCFDA
The citations listed below are publications that use Tocris products. Selected citations for H2DCFDA include:
2 Citations: Showing 1 - 2
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Oxidative stress from DGAT1 oncoprotein inhibition in melanoma suppresses tumor growth when ROS defenses are also breached.
Authors: Andris Et al.
Cell Rep 2022;39:110995
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CRISPR-Cas9 screen identifies oxidative phosphorylation as essential for cancer cell survival at low extracellular pH.
Authors: Walter F Et al.
Cell Rep 2022;38:110493
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