Home / Lysophosphatidic Acid (LPA) Receptor Antagonists / H2L5186303

H2L5186303

Catalog #: 4878
6 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4878/10
4878/50
H2L5186303 | CAS No. 139262-76-3 | Lysophosphatidic Acid (LPA) Receptor Antagonists
1 Image
Description: Potent and selective LPA2 receptor antagonist

Chemical Name: (Z,Z)-4,4'-[1,3-Phenylenebis(oxy-4,1-phenyleneimino)]bis[4-oxo-2-butenoic acid

Purity: ≥98%

Product Details
Citations (6)
Supplemental Products
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

H2L5186303 is a potent and selective lysophosphatidic acid 2 (LPA2) receptor antagonist (IC50 values are 8.9, 1230 and 27354 nM for LPA2, LPA3 and LPA1 receptors respectively, in a LPA-elicited calcium mobilization assay).

Technical Data

M.Wt:
488.45
Formula:
C26H20N2O8
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
139262-76-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Identification of non-lipid LPA3 antagonists by virtual screening.
    Fells et al.
    Bioorg.Med.Chem., 2008;16:6207
  2. Structure-based drug design identifies novel LPA3 antagonists.
    Fells et al.
    Bioorg.Med.Chem., 2009;17:7457

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for H2L5186303

The citations listed below are publications that use Tocris products. Selected citations for H2L5186303 include:

6 Citations: Showing 1 - 6

  1. The lysophosphatidic acid-regulated signal transduction network in ovarian cancer cells and its role in actomyosin dynamics, cell migration and entosis.
    Authors: Robert Et al.
    Theranostics  2023;13:1921-1948
  2. Lysophosphatidic Acid Promotes the Expansion of Cancer Stem Cells via TRPC3 Channels in Triple-Negative Breast Cancer.
    Authors: Shigeru Et al.
    Int J Mol Sci  2022;23
  3. Lysophosphatidic acid induces thrombospondin-1 production in primary cultured rat cortical astrocytes.
    Authors: Yoshihiro Et al.
    J Neurochem  2021;158:849-864
  4. P130Cas/bcar1 mediates zebrafish caudal vein plexus angiogenesis.
    Authors: Paul Et al.
    Sci Rep  2020;10:15589
  5. Mammary Adipose Tissue-Derived Lysophospholipids Promote Estrogen Receptor-Negative Mammary Epithelial Cell Proliferation.
    Authors: Volden Et al.
    Cancer Prev Res (Phila)  2016;9:367
  6. Mechanosensitive PPAP2B Regulates Endothelial Responses to Atherorelevant Hemodynamic Forces.
    Authors: Wu Et al.
    PLoS One  2015;117:e41

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for H2L5186303

There are currently no reviews for this product. Be the first to review H2L5186303 and earn rewards!

Have you used H2L5186303?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.