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HDS 029

Catalog #: 2646
1 Citation Datasheet / COA / SDS

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HDS 029 | CAS No. 881001-19-0 | EGF Receptor Inhibitors
1 Image
Description: Potent inhibitor of the ErbB receptor family

Chemical Name: N-(4-[(-3-Chloro-4-fluorophenyl)amino]pyrido[3,4-d]pyrimidin-6-yl-2-butynamide

Purity: ≥97%

Product Details
Citations (1)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Potent inhibitor of the ErbB receptor family (IC50 values are 0.3, 0.5 and 1.1 nM for ErbB1 (EGFR), ErbB4 and ErbB2 respectively). Inhibits EGF-induced erbB1 autophosphorylation in NIH3T3 cells and heregulin-stimulated ErbB autophosphorylation in MDA-MB-453 human breast carcinoma cells (IC50 values are 2.5 and 24 nM respectively).

Technical Data

M.Wt:
355.76
Formula:
C17H11ClFN5O
Solubility:
Soluble to 25 mM in DMSO
Purity:
≥97%
Storage:
Store at -20°C
CAS No:
881001-19-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citation for HDS 029

The citations listed below are publications that use Tocris products. Selected citations for HDS 029 include:

1 Citation: Showing 1 - 1

  1. A novel glycosylation signal regulates transforming growth factor beta receptors as evidenced by endo-beta-galactosidase C expression in rodent cells.
    Authors: Watanabe Et al.
    Glycobiology  2011;21:482

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