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HEAT hydrochloride

Catalog #: 0535
3 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
0535/10
0535/50
HEAT hydrochloride | CAS No. 30007-39-7 | Adrenergic alpha-1 Receptor Antagonists
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Description: Highly selective α1 antagonist
Alternative Names: BE 2254

Chemical Name: 2-{[β-(4-Hydroxyphenyl)ethyl]aminomethyl}-1-tetralone hydrochloride

Purity: ≥98%

Product Details
Citations (3)
Supplemental Products
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

HEAT hydrochloride is a very selective α1-adrenoceptor antagonist, precursor of the 3-[125I]-derivative.

Technical Data

M.Wt:
331.84
Formula:
C19H21NO2.HCl
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at -20°C
CAS No:
30007-39-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
    Fox JT, Sakamuru S, Huang R
    Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
  2. Mechanisms of pressor effect of 5,6-dihydroxytryptamine in pithed rats.
    Baumgarten et al.
    Naunyn Schmiedebergs Arch.Pharmacol., 1972;274:375
  3. Interaction of 2-[β-(4-hydroxyphenyl)ethylaminomethyl]tetralone (BE 2254: 'HEAT') with catecholamine receptors in rat brain membranes.
    Williams et al.
    J.Pharm.Pharmacol., 1978;30:390

Product Datasheets

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Reconstitution Calculator

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Citations for HEAT hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for HEAT hydrochloride include:

3 Citations: Showing 1 - 3

  1. α1-adrenergic receptors positively regulate Toll-like receptor cytokine production from human monocytes and macrophages.
    Authors: Grisanti Et al.
    J Pharmacol Exp Ther  2011;338:648
  2. Noradrenergic inputs mediate state dependence of auditory responses in the avian song system.
    Authors: Cardin and Schmidt
    Circ Res  2004;24:7745
  3. The NK1 receptor mediates both the hyperalgesia and the resistance to mor. in mice lacking noradrenaline.
    Authors: Jasmin Et al.
    Proc Natl Acad Sci U S A  2002;99:1029

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