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Hexa-D-arginine

Catalog #: 4711
2 Citations Datasheet / COA / SDS

Discontinued Product

4711 has been discontinued.
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Hexa-D-arginine
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Description: Furin inhibitor

Purity: ≥95%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Hexa-D-arginine is an inhibitor of furin (Ki values are 0.106, 0.58 and 13.2 μM for furin, PACE4 and PC1 respectively).

Technical Data

M.Wt:
954.16
Formula:
C36H75N25O6
Sequence:
RRRRRR

(Modifications: Arg-6 = C-terminal amide, Arg-1,2,3,4,5,6 = D-Arg)

Solubility:
Soluble to 2 mg/ml in water
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
673202-67-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Hexa-D-arginine treatment increases 7B2.PC2 activity in hyp-mouse osteoblasts and rescues the HYP phenotype.
    Yuan et al.
    J.Bone Miner.Res., 2012;28:56
  2. Polyarginines are potent furin inhibitors.
    Cameron et al.
    J.Biol.Chem., 2000;275:36741
  3. Dopamine Receptor Activation Modulates the Integrity of the Perisynaptic Extracellular Matrix at Excitatory Synapses
    J Mitlöhner, R Kaushik, H Niekisch, A Blondiaux, CE Gee, MFK Happel, E Gundelfing, A Dityatev, R Frischknec, C Seidenbech
    Cells, 2020;9(2):.
  4. Furin inhibitors block SARS-CoV-2 spike protein cleavage to suppress virus production and cytopathic effects.
    Cheng et al.
    Cell Rep., 2020;

Product Datasheets

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Citations for Hexa-D-arginine

The citations listed below are publications that use Tocris products. Selected citations for Hexa-D-arginine include:

2 Citations: Showing 1 - 2

  1. Furin inhibitors block SARS-CoV-2 spike protein cleavage to suppress virus production and cytopathic effects.
    Authors: Cheng Et al.
    Cell Rep.  2020;
  2. Biowire Model of Interstitial and Focal Cardiac Fibrosis.
    Authors: Wang Et al.
    ACS Cent Sci  2019;5:1146

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