Homoharringtonine

Catalog #: 1416
3 Citations Datasheet / COA / SDS

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1416/10

Homoharringtonine | CAS No. 26833-87-4 | DNA, RNA and Protein Synthesis Inhibitors

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Description: Inhibitor of protein synthesis; antileukemic agent

Chemical Name: Cephalotaxine 4-methyl (2R)-2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate

Purity: ≥98%

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Product Details

Citations (3)

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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Homoharringtonine is an inhibitor of protein synthesis. Blocks elongation phase of translation by binding to the 60-S ribosome subunit. Antileukemic. Inhibits SARS-CoV-2 infection in vitro (IC₅₀ = 2.55 μM).

Technical Data

M.Wt:

545.63

Formula:

C₂₉H₃₉NO₉

Solubility:

Soluble to 100 mM in DMSO

Purity:

≥98%

Storage:

Store at RT

CAS No:

26833-87-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Apoptotic response to homoharringtonine in human wt p53 leukemic cells is independent of reactive oxygen species generation and implicates Bax translocation, mitochondrial cytochrome c release and caspase activation.
Cai et al.
Leukemia, 2001;15:567
Inhibition of translation in eukaryotic systems by harringtonine.
Fresno et al.
Eur.J.Biochem., 1977;72:323
Homoharringtonine: an effective new natural product in cancer chemotherapy.
Zhou et al.
Bull.Cancer, 1995;82:987
Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2 replication in vitro.
Choy et al.
Antiviral Res., 2020;178

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Citations for Homoharringtonine

The citations listed below are publications that use Tocris products. Selected citations for Homoharringtonine include:

3 Citations: Showing 1 - 3

AMPK activation regulates P-body dynamics in mouse sensory neurons in vitro and in vivo.
Authors: Paige Et al.
Neurobiol Pain 2019;5
Splicing promotes the nuclear export of β-globin mRNA by overcoming nuclear retention elements.
Authors: Akef Et al.
Cell J 2015;21:1908
Identification of repurposed small molecule drugs for chordoma therapy.
Authors: Xia Et al.
Cancer Biol Ther 2013;14:638

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