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HU 210

Catalog #: 0966
30 Citations Datasheet / COA / SDS

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0966 has been discontinued.
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HU 210 | CAS No. 112830-95-2 | Non-selective Cannabinoid Receptor Agonists
1 Image
Description: Highly potent cannabinoid receptor agonist

Chemical Name: (6aR)-trans-3-(1,1-Dimethylheptyl)-6a,7,10,10a-tetrahydro-1-hydroxy-6,6-dimethyl-6H-dibenzo[b,d]pyran-9-methanol

Purity: ≥98%

Product Details
Citations (30)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

HU 210 is a highly potent cannabinoid receptor agonist (Ki values are 0.061 and 0.52 nM at cloned human CB1 and CB2 receptors respectively). Induces spatial memory deficits and suppresses hippocampal firing rates in rats. Also displays agonist activity at GPR55 (EC50 = 26 nM).

Technical Data

M.Wt:
386.57
Formula:
C25H38O3
Solubility:
Soluble to 100 mM in ethanol and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
112830-95-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for HU 210

The citations listed below are publications that use Tocris products. Selected citations for HU 210 include:

30 Citations: Showing 1 - 10

  1. Glucose metabolism links astroglial mitochondria to cannabinoid effects.
    Authors: Jimenez-Blasco Et al.
    Nature  2020;
  2. Cannabinoid-Elicited Conditioned Place Preference in a Modified Behavioral Paradigm.
    Authors: Liu Et al.
    Biol Pharm Bull  2016;39:747
  3. Cannabinoid HU210 protects isolated rat stomach against impairment caused by serum of rats with experimental acute pancreatitis.
    Authors: Cao Et al.
    PLoS One  2013;7:e52921
  4. Ghrelin and cannabinoids require the ghrelin receptor to affect cellular energy metabolism.
    Authors: Lim Et al.
    Br J Pharmacol  2013;365:303
  5. Differences in spontaneously avoiding or approaching mice reflect differences in CB1-mediated signaling of dorsal striatal transmission.
    Authors: Laricchiuta Et al.
    PLoS One  2012;7:e33260
  6. Interleukin-1β causes anxiety by interacting with the endocannabinoid system.
    Authors: Rossi Et al.
    J Neurosci  2012;32:13896
  7. Subventricular zone neural progenitors protect striatal neurons from glutamatergic excitotoxicity.
    Authors: Butti Et al.
    Brain  2012;135:3320
  8. Altered gut microbiota and endocannabinoid system tone in obese and diabetic leptin-resistant mice: impact on apelin regulation in adipose tissue.
    Authors: Geurts Et al.
    Front Microbiol  2011;2:149
  9. The endocannabinoid system links gut microbiota to adipogenesis.
    Authors: Muccioli Et al.
    Mol Syst Biol  2010;6:392
  10. CB1 cannabinoid receptors increase neuronal precursor proliferation through AKT/glycogen synthase kinase-3β/β-catenin signaling.
    Authors: Trazzi Et al.
    Br J Pharmacol  2010;285:10098
  11. Inhibitor of fatty acid amide hydrolase normalizes cardiovascular function in hypertension without adverse metabolic effects.
    Authors: Godlewski Et al.
    Chem Biol  2010;17:1256
  12. Cannabinoid-1 receptor activation induces reactive oxygen species-dependent and -independent mitogen-activated protein kinase activation and cell death in human coronary artery endothelial cells.
    Authors: Rajesh Et al.
    Br J Pharmacol  2010;160:688
  13. Cannabinoid receptor 1 is a potential drug target for treatment of translocation-positive rhabdomyosarcoma.
    Authors: Oesch Et al.
    Mol Cancer Ther  2009;8:1838
  14. Cannabinoid receptor activation reverses kainate-induced synchronized population burst firing in rat hippocampus.
    Authors: Mason and Cheer
    Front Integr Neurosci  2009;3:13
  15. Genetic and pharmacological manipulations of the CB(1) receptor alter ethanol preference and dependence in ethanol preferring and nonpreferring mice.
    Authors: Vinod Et al.
    Synapse  2008;62:574
  16. Repeated cannabinoid injections into the rat periaqueductal gray enhance subsequent mor. antinociception.
    Authors: Wilson Et al.
    Neuropharmacology  2008;55:1219
  17. Interactions between CB(1) receptors and TRPV1 channels mediated by 12-HPETE are cytotoxic to mesencephalic DArgic neurons.
    Authors: Kim Et al.
    Br J Pharmacol  2008;155:253
  18. Pharmacological inhibition of CB1 cannabinoid receptor protects against doxorubicin-induced cardiotoxicity.
    Authors: Mukhopadhyay Et al.
    J Am Coll Cardiol  2007;50:528
  19. Cannabinoid action in the olfactory epithelium.
    Authors: Czesnik Et al.
    Proc Natl Acad Sci U S A  2007;104:2967
  20. Induction of Krox-24 by endogenous cannabinoid type 1 receptors in Neuro2A cells is mediated by the MEK-ERK MAPK pathway and is suppressed by the phosphatidylinositol 3-kinase pathway.
    Authors: Graham Et al.
    J Biol Chem  2006;281:29085
  21. Actions of the FAAH inhibitor URB597 in neuropathic and inflammatory chronic pain models.
    Authors: Jayamanne Et al.
    J Biol Chem  2006;147:281
  22. Effects of intra-amygdala infusion of CB1 receptor agonists on the reconsolidation of fear-potentiated startle.
    Authors: Lin Et al.
    Learn Mem  2006;13:316
  23. Identification of WIN55212-3 as a competitive neutral antagonist of the human cannabinoid CB2 receptor.
    Authors: Savinainen Et al.
    Br J Pharmacol  2005;145:636
  24. An optimized approach to study endocannabinoid signaling: evidence against constitutive activity of rat brain adenosine A1 and cannabinoid CB1 receptors.
    Authors: Savinainen Et al.
    Br J Pharmacol  2003;140:1451
  25. Gastric antisecretory role and immunohistochemical localization of cannabinoid receptors in the rat stomach.
    Authors: Adami Et al.
    Br J Pharmacol  2002;135:1598
  26. Targeting CB2 cannabinoid receptors as a novel therapy to treat malignant lymphoblastic disease.
    Authors: McKallip Et al.
    Blood  2002;100:627
  27. Effects of cannabinoid receptor agonists on neuronally-evoked contractions of urinary bladder tissues isolated from rat, mouse, pig, dog, monkey and human.
    Authors: Martin Et al.
    Br J Pharmacol  2000;129:1707
  28. Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice.
    Authors: Zimmer Et al.
    J Biol Chem  1999;96:5780
  29. The actions of some cannabinoid receptor ligands in the rat isolated mesenteric artery.
    Authors: White and Hiley
    Br J Pharmacol  1998;125:533
  30. Cannabinoid CB1 receptor and endothelium-dependent hyperpolarization in guinea-pig carotid, rat mesenteric and porcine coronary arteries.
    Authors: Chataigneau Et al.
    Proc Natl Acad Sci U S A  1998;123:968

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