HU 210
Discontinued Product
Chemical Name: (6aR)-trans-3-(1,1-Dimethylheptyl)-6a,7,10,10a-tetrahydro-1-hydroxy-6,6-dimethyl-6H-dibenzo[b,d]pyran-9-methanol
Purity: ≥98%
Biological Activity
HU 210 is a highly potent cannabinoid receptor agonist (Ki values are 0.061 and 0.52 nM at cloned human CB1 and CB2 receptors respectively). Induces spatial memory deficits and suppresses hippocampal firing rates in rats. Also displays agonist activity at GPR55 (EC50 = 26 nM).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors.
Xiong W, Cui T, Cheng K, Yang F, Chen SR, Willenbring D, Guan Y, Pan HL, Ren K, Xu Y, Zhang L
J. Exp. Med., 2012;209(6):1121-34. -
Interaction between interleukin-1? and type-1 cannabinoid receptor is involved in anxiety-like behavior in experimental autoimmune encephalomyelitis
J Neuroinflammation, 2016;13(1):231. -
The orphan receptor GPR55 is a novel cannabinoid receptor.
Ryberg et al.
Br.J.Pharmacol., 2007;152:1092 -
Stereochemical effects of 11-OH-Δ8-tetrahydrocannabinol-dimethylheptyl to inhibit adenylate cyclase and bind to the cannabinoid receptor.
Howlett et al.
Neuropharmacology, 1990;29:161 -
Enantiomeric cannabinoids: stereospecificity of psychotropic activity.
Mechoulam et al.
Experientia, 1988;44:762 -
The synthetic cannabinoid HU210 reduces spatial memory deficits and suppresses hippocampal firing rates in rats.
Robinson et al.
Br.J.Pharmacol., 2007;151:688
Product Datasheets
Citations for HU 210
The citations listed below are publications that use Tocris products. Selected citations for HU 210 include:
30 Citations: Showing 1 - 10
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Glucose metabolism links astroglial mitochondria to cannabinoid effects.
Authors: Jimenez-Blasco Et al.
Nature 2020;
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Cannabinoid-Elicited Conditioned Place Preference in a Modified Behavioral Paradigm.
Authors: Liu Et al.
Biol Pharm Bull 2016;39:747
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Cannabinoid HU210 protects isolated rat stomach against impairment caused by serum of rats with experimental acute pancreatitis.
Authors: Cao Et al.
PLoS One 2013;7:e52921
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Ghrelin and cannabinoids require the ghrelin receptor to affect cellular energy metabolism.
Authors: Lim Et al.
Br J Pharmacol 2013;365:303
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Differences in spontaneously avoiding or approaching mice reflect differences in CB1-mediated signaling of dorsal striatal transmission.
Authors: Laricchiuta Et al.
PLoS One 2012;7:e33260
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Interleukin-1β causes anxiety by interacting with the endocannabinoid system.
Authors: Rossi Et al.
J Neurosci 2012;32:13896
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Subventricular zone neural progenitors protect striatal neurons from glutamatergic excitotoxicity.
Authors: Butti Et al.
Brain 2012;135:3320
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Altered gut microbiota and endocannabinoid system tone in obese and diabetic leptin-resistant mice: impact on apelin regulation in adipose tissue.
Authors: Geurts Et al.
Front Microbiol 2011;2:149
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The endocannabinoid system links gut microbiota to adipogenesis.
Authors: Muccioli Et al.
Mol Syst Biol 2010;6:392
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CB1 cannabinoid receptors increase neuronal precursor proliferation through AKT/glycogen synthase kinase-3β/β-catenin signaling.
Authors: Trazzi Et al.
Br J Pharmacol 2010;285:10098
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Inhibitor of fatty acid amide hydrolase normalizes cardiovascular function in hypertension without adverse metabolic effects.
Authors: Godlewski Et al.
Chem Biol 2010;17:1256
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Cannabinoid-1 receptor activation induces reactive oxygen species-dependent and -independent mitogen-activated protein kinase activation and cell death in human coronary artery endothelial cells.
Authors: Rajesh Et al.
Br J Pharmacol 2010;160:688
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Cannabinoid receptor 1 is a potential drug target for treatment of translocation-positive rhabdomyosarcoma.
Authors: Oesch Et al.
Mol Cancer Ther 2009;8:1838
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Cannabinoid receptor activation reverses kainate-induced synchronized population burst firing in rat hippocampus.
Authors: Mason and Cheer
Front Integr Neurosci 2009;3:13
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Genetic and pharmacological manipulations of the CB(1) receptor alter ethanol preference and dependence in ethanol preferring and nonpreferring mice.
Authors: Vinod Et al.
Synapse 2008;62:574
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Repeated cannabinoid injections into the rat periaqueductal gray enhance subsequent mor. antinociception.
Authors: Wilson Et al.
Neuropharmacology 2008;55:1219
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Interactions between CB(1) receptors and TRPV1 channels mediated by 12-HPETE are cytotoxic to mesencephalic DArgic neurons.
Authors: Kim Et al.
Br J Pharmacol 2008;155:253
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Pharmacological inhibition of CB1 cannabinoid receptor protects against doxorubicin-induced cardiotoxicity.
Authors: Mukhopadhyay Et al.
J Am Coll Cardiol 2007;50:528
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Cannabinoid action in the olfactory epithelium.
Authors: Czesnik Et al.
Proc Natl Acad Sci U S A 2007;104:2967
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Induction of Krox-24 by endogenous cannabinoid type 1 receptors in Neuro2A cells is mediated by the MEK-ERK MAPK pathway and is suppressed by the phosphatidylinositol 3-kinase pathway.
Authors: Graham Et al.
J Biol Chem 2006;281:29085
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Actions of the FAAH inhibitor URB597 in neuropathic and inflammatory chronic pain models.
Authors: Jayamanne Et al.
J Biol Chem 2006;147:281
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Effects of intra-amygdala infusion of CB1 receptor agonists on the reconsolidation of fear-potentiated startle.
Authors: Lin Et al.
Learn Mem 2006;13:316
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Identification of WIN55212-3 as a competitive neutral antagonist of the human cannabinoid CB2 receptor.
Authors: Savinainen Et al.
Br J Pharmacol 2005;145:636
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An optimized approach to study endocannabinoid signaling: evidence against constitutive activity of rat brain adenosine A1 and cannabinoid CB1 receptors.
Authors: Savinainen Et al.
Br J Pharmacol 2003;140:1451
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Gastric antisecretory role and immunohistochemical localization of cannabinoid receptors in the rat stomach.
Authors: Adami Et al.
Br J Pharmacol 2002;135:1598
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Targeting CB2 cannabinoid receptors as a novel therapy to treat malignant lymphoblastic disease.
Authors: McKallip Et al.
Blood 2002;100:627
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Effects of cannabinoid receptor agonists on neuronally-evoked contractions of urinary bladder tissues isolated from rat, mouse, pig, dog, monkey and human.
Authors: Martin Et al.
Br J Pharmacol 2000;129:1707
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Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice.
Authors: Zimmer Et al.
J Biol Chem 1999;96:5780
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The actions of some cannabinoid receptor ligands in the rat isolated mesenteric artery.
Authors: White and Hiley
Br J Pharmacol 1998;125:533
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Cannabinoid CB1 receptor and endothelium-dependent hyperpolarization in guinea-pig carotid, rat mesenteric and porcine coronary arteries.
Authors: Chataigneau Et al.
Proc Natl Acad Sci U S A 1998;123:968
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