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Human 5-HT1B Antibody

Catalog #: MAB5858
1 Citation Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
MAB5858
MAB5858-SP
Product Details
Citations (1)
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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human 5-HT1B Antibody Summary

Species Reactivity
Human
Specificity
Detects human 5HT1B.
Source
Monoclonal Mouse IgG1 Clone # 499325
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
NS0 mouse myeloma cell line transfected with human 5HT1B
Met1-Ser390
Accession # P28222
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Applications

Recommended Concentration
Sample
Immunohistochemistry
8-25 µg/mL
Immersion fixed paraffin-embedded sections of human brain (cortex and glia)

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS.
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Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: 5-HT1B

5HT1B is a 7TM receptor for serotonin and is expressed on striatal neurons and Purkinje cells in the cerebellum. 5HT1B ligation inhibits glycinergic signaling, appetite, circadian rhythm light responsiveness, and trigeminal-mediated nociception. It is an important pharmacologic target in the treatment of migrane headaches. Human 5HT1B shares 92% aa sequence identity with mouse and rat 5HT1B.

Long Name
5-Hydroxytryptamine Receptor 1B
Entrez Gene IDs
3351 (Human); 15551 (Mouse); 25075 (Rat)
Alternate Names
5HT1B; 5-HT1B; 5-HT1B5-HT-1B; 5HT1DB; 5-HT1DB; 5-hydroxytryptamine (serotonin) receptor 1B; HTR1B; HTR1D2; HTR1D2,5-hydroxytryptamine receptor 1B; HTR1DB; S12; S125-HT-1D-beta; Serotonin 1D beta receptor; Serotonin receptor 1B

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Citation for Human 5-HT1B Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

1 Citation: Showing 1 - 1

  1. Serotonin and Dopamine Receptor Expression in Solid Tumours Including Rare Cancers
    Authors: Marloes A. M. Peters, Coby Meijer, Rudolf S. N. Fehrmann, Annemiek M. E. Walenkamp, Ido P. Kema, Elisabeth G. E. de Vries et al.
    Pathology & Oncology Research

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