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Human Aminopeptidase LRAP/ERAP2 Antibody

Catalog #: MAB3830
5 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
MAB3830
MAB3830-SP
Product Details
Citations (5)
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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human Aminopeptidase LRAP/ERAP2 Antibody Summary

Species Reactivity
Human
Specificity
Detects human Aminopeptidase LRAP/ERAP2 in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross‑reactivity with recombinant human PILS is observed.
Source
Monoclonal Mouse IgG1 Clone # 3F5
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
S. frugiperda insect ovarian cell line Sf 21-derived recombinant human Aminopeptidase LRAP/ERAP2
Accession # Q6P179
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Applications

Recommended Concentration
Sample
Western Blot
1 µg/mL
Recombinant Human Aminopeptidase LRAP/ERAP2 (Catalog # 3830-ZN)

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS.
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Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Aminopeptidase LRAP/ERAP2

Leukocyte-derived arginine aminopeptidase (LRAP) and endoplasmic reticulum-aminopeptidase 2 (ERAP2) are the two names given to the protein encoded by the LRAP gene (1, 2). Induced by interferon-gamma, LRAP is able to trim various MHC class I antigenic peptide precursors. It belongs to the oxytocinase subfamily of M1 aminopeptidases, which also includes aminopeptidases PILS/ARTS1/ERAP1 and LNPEP/PLAP (1, 3). In addition to antigen presentation, the members of this subfamily are also important in maintenance of pregnancy, memory retention, and blood pressure regulation (3).

References
  1. Tanioka, T. et al. (2003) J. Biol. Chem. 278:32275.
  2. Tanioka, T. et al. (2005) FEBS J. 272:916.
  3. Tsujimoto, M. and A. Hattori (2005) Biochim. Biophys. Acta 1751:9.
Long Name
Leukocyte-derived Arginine Aminopeptidase
Entrez Gene IDs
64167 (Human)
Alternate Names
Aminopeptidase LRAP; EC 3.4.11; EC 3.4.11.3; endoplasmic reticulum aminopeptidase 2; ERAP2; FLJ23633; FLJ23701; FLJ23807; Leukocyte-derived arginine aminopeptidase; LRAPL-RAPEC 3.4.11.-

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Citations for Human Aminopeptidase LRAP/ERAP2 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

5 Citations: Showing 1 - 5
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  1. The Protective Action of Metformin against Pro-Inflammatory Cytokine-Induced Human Islet Cell Damage and the Mechanisms Involved
    Authors: L Giusti, M Tesi, F Ciregia, L Marselli, L Zallocco, M Suleiman, C De Luca, S Del Guerra, M Zuccarini, M Trerotola, DL Eizirik, M Cnop, MR Mazzoni, P Marchetti, A Lucacchini, M Ronci
    Cells, 2022-08-08;11(15):.
    Species: Human
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  2. ER-aminopeptidase 1 determines the processing and presentation of an immunotherapy-relevant melanoma epitope
    Authors: K Textoris-T, C Cammann, P Henklein, E Topfstedt, F Ebstein, S Henze, J Liepe, F Zhao, D Schadendor, B Dahlmann, W Uckert, A Paschen, M Mishto, U Seifert
    Eur. J. Immunol., 2019-11-27;0(0):.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  3. Endoplasmic reticulum aminopeptidase 2 involvement in metastasis of oral cavity squamous cell carcinoma discovered by proteome profiling of primary cancer cells
    Authors: IC Kuo, HK Kao, Y Huang, CI Wang, JS Yi, Y Liang, CT Liao, TC Yen, CC Wu, KP Chang
    Oncotarget, 2017-06-27;8(37):61698-61708.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  4. The Beh�et's disease-associated variant of the aminopeptidase ERAP1 shapes a low affinity HLA-B*51 peptidome by differential subpeptidome processing
    Authors: P Guasp, E Barnea, MF González-E, A Jiménez-Re, JR Regueiro, A Admon, JA López de C
    J. Biol. Chem., 2017-04-26;0(0):.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  5. The proteasome immunosubunits, PA28 and ER-aminopeptidase 1 protect melanoma cells from efficient MART-126-35 -specific T-cell recognition.
    Authors: Keller M, Ebstein F, Burger E, Textoris-Taube K, Gorny X, Urban S, Zhao F, Dannenberg T, Sucker A, Keller C, Saveanu L, Kruger E, Rothkotter H, Dahlmann B, Henklein P, Voigt A, Kuckelkorn U, Paschen A, Kloetzel P, Seifert U
    Eur J Immunol, 2015-10-19;45(12):3257-68.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot

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