Human Aminopeptidase LRAP/ERAP2 Antibody Summary
Ala56-Thr960
Accession # Q6P179
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of Human Aminopeptidase LRAP/ERAP2 by Western Blot Immunoblot analyses of ERAP2 using LCL protein extract.Two LCLs of each ERAP2 genotype (AA, AB, and BB) were tested for protein using primary antibodies specific to: A, ERAP2 (goat polyclonal); B, ERAP2 (mouse polyclonal); and C, beta -actin (see Materials and Methods). Image collected and cropped by CiteAb from the following publication (https://dx.plos.org/10.1371/journal.pgen.1001157), licensed under a CC-BY license. Not internally tested by R&D Systems.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: Aminopeptidase LRAP/ERAP2
Leukocyte-derived arginine aminopeptidase (LRAP) and endoplasmic reticulum-aminopeptidase 2 (ERAP2) are the two names given to the protein encoded by the LRAP gene (1, 2). Induced by interferon-gamma, LRAP is able to trim various MHC class I antigenic peptide precursors. It belongs to the oxytocinase subfamily of M1 aminopeptidases, which also includes aminopeptidases PILS/ARTS1/ERAP1 and LNPEP/PLAP (1, 3). In addition to antigen presentation, the members of this subfamily are also important in maintenance of pregnancy, memory retention, and blood pressure regulation (3).
- Tanioka, T. et al. (2003) J. Biol. Chem. 278:32275.
- Tanioka, T. et al. (2005) FEBS J. 272:916.
- Tsujimoto, M. and A. Hattori (2005) Biochim. Biophys. Acta 1751:9.
Product Datasheets
Citations for Human Aminopeptidase LRAP/ERAP2 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 10
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Functionally distinct ERAP1 and ERAP2 are a hallmark of HLA-A29-(Birdshot) Uveitis
Authors: Jonas J W Kuiper, Jessica van van Setten, Matthew Devall, Mircea Cretu-Stancu, Sanne Hiddingh, Roel A Ophoff et al.
Human Molecular Genetics
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A New ERAP2/Iso3 Isoform Expression Is Triggered by Different Microbial Stimuli in Human Cells. Could It Play a Role in the Modulation of SARS-CoV-2 Infection?
Authors: Irma Saulle, Claudia Vanetti, Sara Goglia, Chiara Vicentini, Enrico Tombetti, Micaela Garziano et al.
Cells
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Editing the immunopeptidome of melanoma cells using a potent inhibitor of endoplasmic reticulum aminopeptidase 1 (ERAP1)
Authors: Despoina Koumantou, Eilon Barnea, Adrian Martin-Esteban, Zachary Maben, Athanasios Papakyriakou, Anastasia Mpakali et al.
Cancer Immunology, Immunotherapy
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Endoplasmic reticulum aminopeptidase 2 involvement in metastasis of oral cavity squamous cell carcinoma discovered by proteome profiling of primary cancer cells
Authors: IC Kuo, HK Kao, Y Huang, CI Wang, JS Yi, Y Liang, CT Liao, TC Yen, CC Wu, KP Chang
Oncotarget, 2017-06-27;8(37):61698-61708.
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The Differential Expression of ERAP1/ERAP2 and Immune Cell Activation in Pre-eclampsia
Authors: Kimberly Seamon, Lesia O. Kurlak, Michelle Warthan, Efstratios Stratikos, Jerome F. Strauss, Hiten D. Mistry et al.
Frontiers in Immunology
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The effect of rs2910686 on ERAP2 expression in IBD and epithelial inflammatory response
Authors: Sæterstad, S;Østvik, AE;Hansen, MD;Bruland, T;van Beelen Granlund, A;
Journal of translational medicine
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
ERAP2 Inhibition Induces Cell-Surface Presentation by MOLT-4 Leukemia Cancer Cells of Many Novel and Potentially Antigenic Peptides
Authors: I Temponeras, G Stamatakis, M Samiotaki, D Georgiadis, H Pratsinis, G Panayotou, E Stratikos
International Journal of Molecular Sciences, 2022-02-08;23(3):.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
Interaction between ERAP Alleles and HLA Class I Types Support a Role of Antigen Presentation in Hodgkin Lymphoma Development
Authors: P Jiang, RN Veenstra, A Seitz, IM Nolte, BG Hepkema, L Visser, A van den Be, A Diepstra
Cancers, 2021-01-22;13(3):.
Species: Human
Sample Types: Cell Lysates, Whole Tissue
Applications: IHC, Western Blot -
The role of Endoplasmic Reticulum Aminopeptidase 2 (ERAP2) in modulating immune detection of choriocarcinoma
Authors: MD Warthan, SL Washington, SE Franzese, RM Ramus, KR Kim, TP York, E Stratikos, JF Strauss, ED Lee
Biol. Reprod., 2018-03-01;0(0):.
Species: Human
Sample Types: Cell Lysates, Whole Cells, Whole Tissue
Applications: ICC, IHC-P, Western Blot -
Integrated analysis of fine-needle-aspiration cystic fluid proteome, cancer cell secretome, and public transcriptome datasets for papillary thyroid cancer biomarker discovery
Authors: CC Wu, JD Lin, JT Chen, CM Chang, HF Weng, C Hsueh, HP Chien, JS Yu
Oncotarget, 2018-01-04;9(15):12079-12100.
Species: Human
Sample Types: Cyst Fluid, Whole Tissue
Applications: IHC, Western Blot -
ERAP2 Increases the Abundance of a Peptide Submotif Highly Selective for the Birdshot Uveitis-Associated HLA-A29
Authors: Wouter J. Venema, Sanne Hiddingh, Joke H. de Boer, Frans H. J. Claas, Arend Mulder, Anneke I. den Hollander et al.
Frontiers in Immunology
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Genetic analysis of isoform usage in the human anti-viral response reveals influenza-specific regulation of ERAP2 transcripts under balancing selection
Authors: Chun Jimmie Ye, Jenny Chen, Alexandra-Chloé Villani, Rachel E. Gate, Meena Subramaniam, Tushar Bhangale et al.
Genome Research
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Balancing Selection Maintains a Form of ERAP2 that Undergoes Nonsense-Mediated Decay and Affects Antigen Presentation
Authors: Aida M. Andrés, Megan Y. Dennis, Warren W. Kretzschmar, Jennifer L. Cannons, Shih-Queen Lee-Lin, Belen Hurle et al.
PLoS Genetics
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