Human BCAM Biotinylated Antibody Summary
Glu32-Ala547
Accession # CAA58449
Applications
Human BCAM Sandwich Immunoassay
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: BCAM
Basal-Cell Adhesion Molecule (BCAM) and Lutheran blood group glycoprotein (LU) are two alternatively spliced variants of a single immunoglobulin superfamily (IgSF) protein that differ in the length of their cytoplasmic tails. BCAM cDNA encodes a 628 amino acid (aa) residues precursor protein with a putative 31 aa signal peptide, a 597 aa extracellular domain containing three C2 type and two V-type Ig like domains, a 21 aa transmembrane domain, and a 19 aa cytoplasmic domain. Compared to the 40 aa cytoplasmic domain present in LU, the BCAM cytoplasmic tail lacks the putative Src homology 3 (SH3) binding site that may be involved in mediating intracellular signaling. BCAM/LU has wide tissue distribution and is expressed on erythrocytes, the endothelium of blood vessels and on the basal layer of cells in the epithelia. The expression of BCAM/LU in normal tissues is higher in fetal versus adult tissues. BCAM/LU expression is also upregulated in sickle cell disease red blood cells, in activated keratinocytes and following malignant transformation in some cell types in vivo and in vitro. BCAM/LU has been shown to be an adhesion molecule that binds laminin, a basement membrane protein involved in cell differentiation, adhesion, migration and proliferation.
- Campbell, I.G. et al. (1994) Cancer Research 54:5761.
- Parsons, S.F. et al. (1995) Proc. Natl. Acad. Sci. USA 92:5496.
- Udani, M. et al. (1998) J. Clin. Invest. 101:2550.
- Schon, M. et al. (2000) J. Invest. Dermatol. 115:1047.
Product Datasheets
Citations for Human BCAM Biotinylated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 3
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Abnormal properties of red blood cells suggest a role in the pathophysiology of Gaucher disease.
Authors: Franco, Melanie, Collec, Emmanuel, Connes, Philippe, van den Akker, Emile, Billette de Villemeur, Thierry, Belmatoug, Nadia, von Lindern, Marieke, Ameziane, Nejma, Hermine, Olivier, Colin, Yves, Le Van Kim, Caroline, Mignot, Cyril
Blood, 2012-12-03;121(3):546-55.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
Novel role for the Lu/BCAM-spectrin interaction in actin cytoskeleton reorganization.
Authors: Collec E, Lecomte MC, El Nemer W, Colin Y, Le Van Kim C
Biochem. J., 2011-06-15;436(3):699-708.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
Decreased sickle red blood cell adhesion to laminin by hydroxyurea is associated with inhibition of Lu/BCAM protein phosphorylation.
Authors: Bartolucci P, Chaar V, Picot J, Bachir D, Habibi A, Fauroux C, Galacteros F, Colin Y, Le Van Kim C, El Nemer W
Blood, 2010-06-21;116(12):2152-9.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot
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