Human BDNF (NP_001700.2) VersaClone cDNA

Human BDNF (NP_001700.2) VersaClone cDNA Summary

Specifications

Product Datasheets

Background: BDNF

BDNF (Brain-Derived Neurotrophic Factor) is a secreted protein that regulates many aspects of neuronal development and function in the nervous system. It is produced as proBDNF in response to neuronal activity or inflammatory stimulation and is then cleaved before associating into a homodimer. It is expressed throughout the nervous system as well as by fibroblasts, megakaryocytes/platelets, and smooth muscle cells. BDNF regulates neural stem cell survival and differentiation, axon/dendrite differentiation, synapse formation and maturation, and refinement of developing circuits. It is also a key regulator of synaptic plasticity and late-phase long-term potentiation. BDNF signals through the TrkB and NGF R/TNFRSF16 receptors. Secreted proBDNF can bind to NGF R/TNFRSF16 and induce long-term depression and cell apoptosis.

Related Research Areas

• Adult Neurogenesis
• Developmental Factors Implicated in Neurodegeneration
• Diabetes
• Diabetic Peripheral Neuropathy
• Microglia Activation Markers
• Microglia Homeostasis
• Microglia Steady-State Markers
• Neuroinflammatory Factors
• Neurotrophic Factors and Receptors
• Neurotrophin/Trk Family
• Obesity
• VPS10P-domain Family