Human BMPR-IB/ALK-6 APC-conjugated Antibody Summary
Lys14-Arg126
Accession # O00238
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of BMPR‑IB/ALK‑6 in PC‑3 Human Cell Line by Flow Cytometry. PC-3 human prostate cancer cell line was stained with Mouse Anti-Human BMPR-IB/ALK-6 APC-conjugated Monoclonal Antibody (Catalog # FAB5051A, filled histogram) or isotype control antibody (Catalog # IC0041A, open histogram). View our protocol for Staining Membrane-associated Proteins.
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Detection of BMPR‑IB/ALK‑6 in Human iPS cells differentiated to Mesoderm by Flow Cytometry. Human iPS cells differentiated to mesoderm (using Catalog # SC030B) were stained with Mouse Anti-Human BMPR-IB/ALK-6 APC-conjugated Monoclonal Antibody (Catalog # FAB5051A, filled histogram) or isotype control antibody (Catalog # IC0041A, open histogram). View our protocol for Staining Membrane-associated Proteins.
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Preparation and Storage
- 12 months from date of receipt, 2 to 8 °C as supplied.
Background: BMPR-IB/ALK-6
Cellular responses to bone morphogenetic proteins (BMPs) have been shown to be mediated by the formation of hetero-oligomeric complexes of the type I and type II serine/threonine kinase receptors. BMP receptor IB (BMPR-IB), also known as activin receptor-like kinase (ALK)-6, is one of seven known type I serine/threonine kinases that are required for the signal transduction of TGF-beta family cytokines. In contrast to the TGF-beta receptor system in which the type I receptor does not bind TGF-beta in the absence of the type II receptor, type I receptors involved in BMP signaling (including BMPR-IA, BMPR-IB/ALK-6, and ActR-I/ALK-2) can independently bind the various BMP family proteins in the absence of type II receptors. Recombinant soluble BMPR-IB binds BMP-4 with high-affinity in solution and is a potent BMP-4 antagonist in vitro. BMPR-IB is expressed in various tissues during embryogenesis. In adult tissues, BMPR-IB is only found in the brain. The extracellular domain of BMPR-IB shares little amino acid sequence identity with the other mammalian ALK type I receptor kinases, but the cysteine residues are conserved. Human and mouse BMPR-IB are highly conserved and share 98% amino acid sequence identity.
- Kawabata, M. et al. (1998) Cytokine and Growth Factor Reviews 9:49.
- Ebendal, T. et al. (1998) J. Neuroscience Research 51:139.
Product Datasheets
Citations for Human BMPR-IB/ALK-6 APC-conjugated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Osteogenic differentiation of human mesenchymal stromal cells and fibroblasts differs depending on tissue origin and replicative senescence
Authors: V Grotheer, N Skrynecki, L Oezel, J Grassmann, J Windolf, CV Suschek
Scientific Reports, 2021-06-07;11(1):11968.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Chronic myeloid leukaemia cells require the bone morphogenic protein pathway for cell cycle progression and self-renewal
Authors: P Toofan, C Busch, H Morrison, S O'Brien, H Jørgensen, M Copland, H Wheadon
Cell Death Dis, 2018-09-11;9(9):927.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Mapping molecular landmarks of human skeletal ontogeny and pluripotent stem cell-derived articular chondrocytes
Authors: GB Ferguson, B Van Handel, M Bay, P Fiziev, T Org, S Lee, R Shkhyan, NW Banks, M Scheinberg, L Wu, B Saitta, J Elphingsto, AN Larson, SM Riester, AD Pyle, NM Bernthal, HK Mikkola, J Ernst, AJ van Wijnen, M Bonaguidi, D Evseenko
Nat Commun, 2018-09-07;9(1):3634.
Species: Human
Sample Types: Whole Cells
Applications: Cell Selection
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