Human Bradykinin RB2/BDKRB2 Alexa Fluor® 647-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: Bradykinin RB2/BDKRB2

Bradykinin RB2 (BDKRB2) is a receptor for bradykinin. The 9 aa bradykinin peptide elicits many responses including vasodilation, edema, smooth muscle spasm and pain fiber stimulation. BDKRB2 expression is widespread in normal smooth muscle tissue and neurons. BDKRB2 associates with G proteins that stimulate a phosphatidylinositol-calcium second messenger system. BDKRB2 forms a complex with PECAM1 and GNAQ and interacts with PECAM1. Aging cardiac endothelial cells gradually lose their capacity to express BDKRB2. This loss appears to be parallel with a loss of the angiogenic potential of the aging cells.

Product Datasheets

Product Specific Notices

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Related Research Areas

• Coagulation
• Complement Pathway
• Peptide Receptors on Endothelial Cells
• Plasmin/Plasminogen and Kallikrein/Kinin Systems
• Receptors in the Jak/STAT Pathway
• Renal Markers
• TGF-beta Superfamily
• Vasoactive Peptide Hormones and Regulators