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Human Cadherin-17 Antibody

Catalog #: MAB1032
5 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
MAB1032-SP
MAB1032-100
MAB1032-500
Detection of Human Cadherin‑17 by Western Blot.
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Product Details
Citations (5)
FAQs
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Summary Data Examples Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human Cadherin-17 Antibody Summary

Species Reactivity
Human
Specificity
Detects human Cadherin-17 in direct ELISAs and Western blots. In direct ELISAs and Western blots, this antibody does not cross-react with recombinant human (rh) Cadherin‑8, rhE‑Cadherin, rhP‑Cadherin, or rhVE‑Cadherin.
Source
Monoclonal Mouse IgG1 Clone # 141713
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
Mouse myeloma cell line NS0-derived recombinant human Cadherin‑17
Gln23-Met787
Accession # CAA58231
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Western Blot
1 µg/mL
See below
Immunohistochemistry
0.5-25 µg/mL
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Western Blot Detection of Human Cadherin‑17 antibody by Western Blot. View Larger

Detection of Human Cadherin‑17 by Western Blot. Western blot shows lysates of human colon tissue. PVDF membrane was probed with 1 µg/mL of Mouse Anti-Human Cadherin-17 Monoclonal Antibody (Catalog # MAB1032) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # HAF018). A specific band was detected for Cadherin-17 at approximately 125 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

Immunohistochemistry Cadherin-17 antibody in Human Ascending Colon by Immunohistochemistry (IHC-P). View Larger

Cadherin‑17 in Human Ascending Colon. Cadherin-17 was detected in immersion fixed paraffin-embedded sections of human ascending colon using Mouse Anti-Human Cadherin-17 Monoclonal Antibody (Catalog # MAB1032) at 0.5 µg/mL overnight at 4 °C. Tissue was stained using the NorthernLights™ 557-conjugated Anti-Mouse IgG Secondary Antibody (red; Catalog # NL007) and counterstained with DAPI (blue).

Immunohistochemistry Cadherin-17 antibody in Human Transverse Colon by Immunohistochemistry (IHC-P). View Larger

Cadherin‑17 in Human Transverse Colon. Cadherin-17 was detected in immersion fixed paraffin-embedded sections of human transverse colon using Mouse Anti-Human Cadherin-17 Monoclonal Antibody (Catalog # MAB1032) at 0.5 µg/mL overnight at 4 °C. Tissue was stained using the NorthernLights™ 557-conjugated Anti-Mouse IgG Secondary Antibody (red; Catalog # NL007) and counterstained with DAPI (blue).

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS.
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Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Cadherin-17

Cadherin-17, also known as liver-intestine (LI) Cadherin, belongs to the cadherin family of calcium-dependent cell adhesion molecules. It associates homotypically and is selectively expressed on gastric and intestinal mucosa.

Entrez Gene IDs
1015 (Human); 12557 (Mouse)
Alternate Names
cadherin 17, LI cadherin (liver-intestine); cadherin; cadherin-16; Cadherin17; Cadherin-17; CDH16; CDH17; FLJ26931; HPT-1 cadherin; HPT1; HPT-1; human intestinal peptide-associated transporter HPT-1; human peptide transporter 1; Intestinal peptide-associated transporter HPT-1; LI cadherin; LI-cadherin; Liver-intestine cadherin; MGC138218; MGC142024

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Citations for Human Cadherin-17 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

5 Citations: Showing 1 - 5
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  1. Associations Between Cardiac Fibrosis and Permanent Atrial Fibrillation in Advanced Heart Failure
    Authors: B. ALDHOON, T. KUČERA, N. SMORODINOVÁ, J. MARTÍNEK, V. MELENOVSKÝ, J. KAUTZNER
    Physiological Research
  2. Functional human gastrointestinal organoids can be engineered from three primary germ layers derived separately from pluripotent stem cells
    Authors: AK Eicher, DO Kechele, N Sundaram, HM Berns, HM Poling, LE Haines, JG Sanchez, K Kishimoto, M Krishnamur, L Han, AM Zorn, MA Helmrath, JM Wells
    Cell Stem Cell, 2021-12-01;0(0):.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  3. Expression Analysis of Fibronectin Type III Domain-Containing (FNDC) Genes in Inflammatory Bowel Disease and Colorectal Cancer
    Authors: T Wuensch, J Wizenty, J Quint, W Spitz, M Bosma, O Becker, A Adler, W Veltzke-Sc, M Stockmann, S Weiss, M Biebl, J Pratschke, F Aigner
    Gastroenterol Res Pract, 2019-04-09;2019(0):3784172.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  4. Targeting cadherin-17 inactivates Ras/Raf/MEK/ERK signaling and inhibits cell proliferation in gastric cancer.
    Authors: Lin Z, Zhang C, Zhang M, Xu D, Fang Y, Zhou Z, Chen X, Qin N, Zhang X
    PLoS ONE, 2014-01-20;9(1):e85296.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  5. Differential protein expression on the cell surface of colorectal cancer cells associated to tumor metastasis.
    Authors: Luque-Garcia JL, Martinez-Torrecuadrada JL, Epifano C, Canamero M, Babel I, Casal JI
    Proteomics, 2010-03-01;10(5):940-52.
    Species: Human
    Sample Types: Cell Lysates, Whole Cells, Whole Tissue
    Applications: ICC, IHC, Western Blot

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