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Human CAR/NR1I3 Antibody

Catalog #: PP-N4111-00
8 Citations Datasheet / COA / SDS
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PP-N4111-00
Product Details
Citations (8)
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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human CAR/NR1I3 Antibody Summary

Species Reactivity
Human
Source
Monoclonal Mouse IgG1 Clone # N4111
Formulation
A liquid formulation in physiologic saline with 0.1% NaN3.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Western Blot
Please refer to the PDF datasheet for specifications.
Immunohistochemistry
Please refer to the PDF datasheet for specifications.
Immunoprecipitation
Please refer to the PDF datasheet for specifications.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Shipping
The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store the unopened product at -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Background: CAR/NR1I3

CAR, (MB67; NR1I3) is a 40 kDa member of the NR1 subfamily of the nuclear hormone receptor family. CAR is predominantly expressed in the liver and forms a heterodimer with RXR. The CAR/RXR heterodimer activates retinoic acid, xenobiotic and phenobarbital response elements. There are two isoforms of the CAR nuclear hormone receptor. Each contains a DNA-binding hinge and dimerization domain. One is full-length at 352 amino acids while the other shows a 4 amino acid truncation at the extreme C-terminus.

Long Name
Constitutive Androstane Receptor
Entrez Gene IDs
9970 (Human)
Alternate Names
CAR; CARCAR1; Constitutive activator of retinoid response; constitutive active receptor; Constitutive active response; Constitutive androstane receptor; MB67; MGC150433; MGC97144; MGC97209; NR1I3; nuclear receptor subfamily 1 group I member 3; nuclear receptor subfamily 1, group I, member 3; orphan nuclear hormone receptor; Orphan nuclear receptor MB67

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Citations for Human CAR/NR1I3 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

8 Citations: Showing 1 - 8
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  1. Molecular basis of crosstalk in nuclear receptors: heterodimerization between PXR and CAR and the implication in gene regulation
    Authors: MN Bwayi, E Garcia-Mal, SC Chai, B Xie, S Chodankar, AD Huber, J Wu, K Annu, WC Wright, HM Lee, J Seetharama, J Wang, CD Buchman, J Peng, T Chen
    Nucleic Acids Research, 2022-04-08;0(0):.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  2. Cisplatin-mediated activation of glucocorticoid receptor induces platinum resistance via MAST1
    Authors: C Pan, J Kang, JS Hwang, J Li, AC Boese, X Wang, L Yang, TJ Boggon, GZ Chen, NF Saba, DM Shin, KR Magliocca, L Jin, S Kang
    Nature Communications, 2021-08-16;12(1):4960.
    Species: Human
    Sample Types: Whole Cells, Whole Tissue
    Applications: ICC, IHC
  3. Impaired Hepatic Adaptation to Chronic Cholestasis induced by Primary Sclerosing Cholangitis
    Sci Rep, 2016-12-23;6(0):39573.
    Species: Human
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  4. Proteasomal interaction as a critical activity modulator of the human constitutive androstane receptor.
    Authors: Chen, Tao, Laurenzana, Elizabet, Coslo, Denise M, Chen, Fengming, Omiecinski, Curtis J
    Biochem J, 2014-02-15;458(1):95-107.
    Species: Primate - Chlorocebus aethiops (African Green Monkey)
    Sample Types: Cell Lysates
    Applications: Western Blot
  5. Regulation of the human hydroxysteroid sulfotransferase (SULT2A1) by RORα and RORγ and its potential relevance to human liver diseases.
    Mol Endocrinol, 2012-12-04;27(1):106-15.
    Species: Human
    Sample Types: Cell Lysates
    Applications: ChIP
  6. Contribution of nutritional deficit to the pathogenesis of the nonthyroidal illness syndrome in critical illness: a rabbit model study.
    Authors: Mebis L, Eerdekens A, Guiza F, Princen L, Derde S, Vanwijngaerden YM, Vanhorebeek I, Darras VM, Van den Berghe G, Langouche L
    Endocrinology, 2011-12-13;153(2):973-84.
    Species: Rabbit
    Sample Types: Whole Tissue
    Applications: IHC-P
  7. Garlic Extract Diallyl Sulfide (DAS) Activates Nuclear Receptor CAR to Induce the Sult1e1 Gene in Mouse Liver.
    Authors: Sueyoshi T, Green WD, Vinal K, Woodrum TS, Moore R, Negishi M
    PLoS ONE, 2011-06-15;6(6):e21229.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Western Blot
  8. Nuclear receptor coactivator 6 mediates the synergistic activation of human cytochrome P-450 2C9 by the constitutive androstane receptor and hepatic nuclear factor-4alpha.
    Authors: Surapureddi S, Rana R, Reddy JK, Goldstein JA
    Mol. Pharmacol., 2008-06-13;74(3):913-23.
    Species: Human
    Sample Types: Cell Lysates
    Applications: ChIP, Western Blot

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