Human CCL18/PARC Antibody Summary
Ala21-Ala89
Accession # P55774.1
Applications
Human CCL18/PARC Sandwich Immunoassay
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: CCL18/PARC
CCL18, also known as alternative macrophage activation-associated CC chemokine (AMAC)-1, macrophage inflammatory protein 4 (MIP-4), and dendritic cell chemokine (DC‑CK1), is a novel CC chemokine that is highly homologous to MIP-1 alpha (61% amino acid (aa) sequence identity). CCL18 cDNA encodes an 89 aa residue precursor protein with a 20 aa putative signal peptide that is cleaved to generate a 69 aa residue mature protein which lacks potential glycosylation sites. In vitro, CCL18 mRNA expression is induced in alternatively activated macrophages by Th2 cytokines such as IL-4, IL-10, and IL-13, and inhibited by IFN-gamma. CCL18 mRNA is also expressed by GM-CSF/IL-4-induced monocyte-derived dendritic cells. In vivo, CCL18 is highly expressed in lung and placenta but is not expressed in epidermal Langerhans cells. Recombinant CCL18 has been shown to chemoattract naive T cells but not monocytes or neutrophils.
Product Datasheets
Citations for Human CCL18/PARC Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
9
Citations: Showing 1 - 9
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Investigation of CCL18 and A1AT as potential urinary biomarkers for bladder cancer detection.
Authors: Miyake M, Ross S, Lawton A et al.
BMC Urol.
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CC-Chemokine Ligand 18 Is an Independent Prognostic Marker in Lymph Node-positive Non-small Cell Lung Cancer
Authors: SEVERIN SCHMID, AGNES CSANADI, NIKOLA KOZHUHAROV, MARCEAU TCHUDJIN, CLAUDIA KAYSER, JUSTYNA RAWLUK et al.
Anticancer Research
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Epstein-Barr virus-induced VEGF and GM-CSF drive nasopharyngeal carcinoma metastasis via recruitment and activation of macrophages
Authors: D Huang, S Song, ZZ Wu, W Wu, X Cui, JN Chen, MS Zeng, S Su
Cancer Res., 2017-05-08;0(0):.
Species: Human
Sample Types: Whole Tissue
Applications: IHC -
Interleukin-10 and prostaglandin E2 have complementary but distinct suppressive effects on Toll-like receptor-mediated dendritic cell activation in ovarian carcinoma
Authors: E Brencicova, AL Jagger, HG Evans, M Georgouli, A Laios, S Attard Mon, G Mehra, J Spencer, AA Ahmed, S Raju-Kanki, LS Taams, SS Diebold
PLoS ONE, 2017-04-14;12(4):e0175712.
Species: Human
Sample Types: Cell Culture Supernates
Applications: ELISA Development (Capture) -
Blocking the recruitment of naive CD4(+) T cells reverses immunosuppression in breast cancer
Authors: S Su, J Liao, J Liu, D Huang, C He, F Chen, L Yang, W Wu, J Chen, L Lin, Y Zeng, N Ouyang, X Cui, H Yao, F Su, JD Huang, J Lieberman, Q Liu, E Song
Cell Res, 2017-03-14;0(0):.
Species: Human
Sample Types: Whole Cells, Whole Tissue
Applications: Functional Assay, ICC, IHC -
Multiplex serum protein analysis reveals potential mechanisms and markers of response to hyperimmune caprine serum in systemic sclerosis
Authors: N Quillinan, KE Clark, B Youl, J Vernes, D McIntosh, S Haq, CP Denton
Arthritis Res. Ther, 2017-03-07;19(1):45.
Species: Human
Sample Types: Serum
Applications: ELISA Development (Capture) -
Osseous manifestations of adult Gaucher disease in the era of enzyme replacement therapy.
Authors: Deegan PB, Pavlova E, Tindall J
Medicine (Baltimore), 2011-01-01;90(1):52-60.
Species: Human
Sample Types: Plasma
Applications: Luminex Development -
Potential biomarkers of osteonecrosis in Gaucher disease.
Authors: Pavlova EV, Deegan PB, Tindall J, McFarlane I, Mehta A, Hughes D, Wraith JE, Cox TM
Blood Cells Mol. Dis., 2010-11-13;46(1):27-33.
Species: Human
Sample Types: Serum
Applications: Luminex Development -
The dendritic cell-specific chemokine, dendritic cell-derived CC chemokine 1, enhances protective cell-mediated immunity to murine malaria.
Authors: Bruna-Romero O, Schmieg J, Del Val M, Buschle M, Tsuji M
J. Immunol., 2003-03-15;170(6):3195-203.
Species: Mouse
Sample Types: Whole Cells
Applications: ICC
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We used this antibody in an in-house ELISA along with pAb (AF394) and protein (394-PA-010) to detect CCL18 in human serum and plasma. This combination detected CCL18 in human serum and plasma efficiently and generated a good standard curve.
