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Human CCL2/JE/MCP-1 Antibody

Catalog #: MAB2791
20 Citations 1 Review Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
MAB2791-SP
MAB2791-100
MAB2791-500
CCL2/JE/MCP‑1 in Human Breast Cancer Tissue.
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Product Details
Citations (20)
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Reviews (1)
Summary Data Examples Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human CCL2/JE/MCP-1 Antibody Summary

Species Reactivity
Human
Specificity
Detects human CCL2/JE/MCP-1 in ELISAs and Western blots. In ELISAs, does not cross-react with recombinant human CCL1, 3, 4, 5, 7, 8, 11, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, recombinant mouse CCL1, 2, 3, 4, 5, 6, 7, 9/10/MIP-1 gamma, 11, 12, 17, 19, 20, 21, 22, 24, 25, or recombinant rat CCL20.
Source
Monoclonal Mouse IgG2B Clone # 23002
Purification
Protein A or G purified from ascites
Immunogen
E. coli-derived recombinant human CCL2/MCP-1
Gln24-Thr99
Accession # P13500
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Immunohistochemistry
8-25 µg/mL
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Immunohistochemistry CCL2/JE/MCP-1 antibody in Human Breast Cancer Tissue by Immunohistochemistry (IHC-P). View Larger

CCL2/JE/MCP‑1 in Human Breast Cancer Tissue. CCL2/JE/MCP-1 was detected in immersion fixed paraffin-embedded sections of human breast cancer tissue using 25 µg/mL Mouse Anti-Human CCL2/JE/MCP-1 Monoclonal Antibody (Catalog # MAB2791) overnight at 4 °C. Tissue was stained with the Anti-Mouse HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS002) and counterstained with hematoxylin (blue). View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS.
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Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: CCL2/JE/MCP-1

MCP-1 is a beta -chemokine that has been designated CCL2. It is produced by a variety of cell types and is chemotactic for monocytes.

Entrez Gene IDs
6347 (Human); 20296 (Mouse); 24770 (Rat); 403981 (Canine)
Alternate Names
C-C motif chemokine ligand 2; CCL2; GDCF-2; HC11; HSMCR30; MCAF; Mcp1; MCP-1; SCYA2; SMC-CF

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Citations for Human CCL2/JE/MCP-1 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

20 Citations: Showing 1 - 10
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  1. HER2 signaling regulates the tumor immune microenvironment and trastuzumab efficacy
    Authors: Triulzi T, Forte L, Regondi V et al.
    OncoImmunology
  2. Extreme Diversity of the Human Vascular Mesenchymal Cell Landscape
    Authors: LE Bruijn, BEWM van den Ak, CM van Rhijn, JF Hamming, JHN Lindeman
    J Am Heart Assoc, 2020-11-16;9(23):e017094.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  3. Appropriate Surgical Treatment of Symptomatic Primary Varicose Veins Decreases Systemic Inflammatory Biomarkers
    Authors: Hiroki Arase, Noriko Sugasawa, Youhei Kawatani, Mikio Sugano, Hirotsugu Kurobe, Eiki Fujimoto et al.
    Annals of Vascular Diseases
  4. Chronic Inflammation Directs an Olfactory Stem Cell Functional Switch from Neuroregeneration to Immune Defense
    Authors: M Chen, RR Reed, AP Lane
    Cell Stem Cell, 2019-09-12;25(4):501-513.e5.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  5. Estrogen promotes progression of hormone-dependent breast cancer through CCL2-CCR2 axis by upregulation of Twist via PI3K/AKT/NF-?B signaling
    Authors: R Han, S Gu, Y Zhang, A Luo, X Jing, L Zhao, X Zhao, L Zhang
    Sci Rep, 2018-06-22;8(1):9575.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  6. Human Parvovirus Infection of Human Airway Epithelia Induces Pyroptotic Cell Death by Inhibiting Apoptosis
    Authors: Xuefeng Deng, Wei Zou, Min Xiong, Zekun Wang, John F. Engelhardt, Shui Qing Ye et al.
    Journal of Virology
  7. An initial investigation into endothelial CC chemokine expression in the human rheumatoid synovium.
    Authors: Rump L, Mattey D, Kehoe O, Middleton J
    Cytokine, 2017-09-01;97(0):133-140.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  8. Isoglutaminyl cyclase contributes to CCL2-driven neuroinflammation in Alzheimer’s disease
    Authors: Maike Hartlage-Rübsamen, Alexander Waniek, Juliane Meissner, Markus Morawski, Stephan Schilling, Carsten Jäger et al.
    Acta Neuropathologica
  9. Discrepancy in CCL2 and CCR2 expression in white versus grey matter hippocampal lesions of Multiple Sclerosis patients
    Authors: Marloes Prins, Ranjan Dutta, Bart Baselmans, John J P Brevé, John G J M Bol, Sadie A Deckard et al.
    Acta Neuropathologica Communications
  10. Cessation of CCL2 inhibition accelerates breast cancer metastasis by promoting angiogenesis.
    Authors: Bonapace L, Coissieux M, Wyckoff J, Mertz K, Varga Z, Junt T, Bentires-Alj M
    Nature, 2014-10-22;515(7525):130-3.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC-P
  11. Skin Gene Expression Correlates of Severity of Interstitial Lung Disease in Systemic Sclerosis
    Authors: Shervin Assassi, Minghua Wu, Filemon K. Tan, Jeffrey Chang, Tiffany A. Graham, Daniel E. Furst et al.
    Arthritis & Rheumatism
  12. Impact of Tumor Vascularity on Responsiveness to Anti-angiogenesis in a Prostate Cancer Stem Cell-derived Tumor Model
    Authors: Kexiong Zhang, David J. Waxman
    Molecular Cancer Therapeutics
  13. Aberrant expression of selectin E, CXCL1, and CXCL13 in chronic endometritis
    Authors: Kotaro Kitaya, Tadahiro Yasuo
    Modern Pathology
  14. The expression of osteoclastogenesis-associated factors and osteoblast response to osteolytic prostate cancer cells
    Authors: Colm Morrissey, Janice S. Lai, Lisha G. Brown, Ya-Chun Wang, Martine P. Roudier, Ilsa M. Coleman et al.
    The Prostate
  15. Altered levels of CC chemokines during pulmonary CMV predict BOS and mortality post-lung transplantation.
    Authors: Weigt SS, Elashoff RM, Keane MP, Strieter RM, Gomperts BN, Xue YY, Ardehali A, Gregson AL, Kubak B, Fishbein MC, Saggar R, Ross DJ, Lynch JP, Zisman DA, Belperio JA
    Am. J. Transplant., 2008-07-01;8(7):1512-22.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC-P
  16. Exploring human testicular peritubular cells: identification of secretory products and regulation by tumor necrosis factor-alpha.
    Authors: Schell C, Albrecht M, Mayer C, Schwarzer JU, Frungieri MB, Mayerhofer A
    Endocrinology, 2008-01-10;149(4):1678-86.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  17. The monocyte chemoattractant protein-1/cognate CC chemokine receptor 2 system affects cell motility in cultured human podocytes.
    Authors: Burt D, Salvidio G, Tarabra E, Barutta F, Pinach S, Dentelli P, Camussi G, Perin PC, Gruden G
    Am. J. Pathol., 2007-11-30;171(6):1789-99.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  18. Invasive chronic inflammatory monocyte phenotype in subjects with high HIV-1 viral load.
    Authors: Pulliam L, Sun B, Rempel H
    J. Neuroimmunol., 2004-12-01;157(1):93-8.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  19. Senescent Tumor Cells Build a Cytokine Shield in Colorectal Cancer
    Authors: Choi YW, Kim YH, Oh SY et al.
    Advanced Science
  20. Atypical Chemokine Receptor 1 (DARC/ACKR1) in Breast Tumors Is Associated with Survival, Circulating Chemokines, Tumor-Infiltrating Immune Cells, and African Ancestry.
    Authors: Jenkins B D, Martini R N et al.
    Cancer Epidemiol Biomarkers Prev

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Reviews for Human CCL2/JE/MCP-1 Antibody

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Human CCL2/JE/MCP-1 Antibody
By Anonymous on 09/02/2021
Application: IHC Sample Tested: synovium Species: Human
Immunohistochemistry Human CCL2/JE/MCP-1 Antibody MAB2791