Human CD-M6PR Lumenal Domain Biotinylated Antibody

Catalog #: BAF5320 Datasheet / COA / SDS

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BAF5320

All CD-M6PR Antibodies

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Human CD-M6PR Lumenal Domain Biotinylated Antibody Summary

Species Reactivity

Human

Specificity

Detects human CD-M6PR Lumenal Domain in Western blots. In Western blots, approximately 40% cross‑reactivity with recombinant mouse CD-M6PR is observed.

Source

Polyclonal Goat IgG

Purification

Antigen Affinity-purified

Immunogen

Mouse myeloma cell line NS0-derived recombinant human CD-M6PR Lumenal Domain

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.

Label

Biotin

Applications

Recommended Concentration

Sample

Western Blot

0.1 µg/mL

Recombinant Human CD-M6PR Lumenal Domain

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Reconstitution

Reconstitute at 0.2 mg/mL in sterile PBS.

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: CD-M6PR

The CD-M6PR (cation-dependent mannose 6-phosphate receptor; also CD-MPR) is a 44‑46 kDa member of the P-type lectin family of proteins. It is ubiquitously expressed, found internally, and transports newly formed mannose 6-phosphate bearing acid hydrolases from the secretory pathway to acidified lysosomes. Mature human CD-M6PR is a type I transmembrane glycoprotein that is 251 amino acids (aa) in length. It functions as a homodimer, and contains a 159 aa luminal region (aa 27‑185) plus a 67 aa cytoplasmic domain. The aa residues Gln66, Arg111, Glu133 and Tyr143 recognize carbohydrate; Asp103 interacts with divalent cation (Mn2⁺), increasing ligand affinity and receptor oligomerization. Over aa 27‑184, human CD-M6PR shares 90% aa identity with mouse CD-M6PR.

Long Name

Cation Dependent Mannose-6-Phosphate Receptor 46 kDa

Entrez Gene IDs

4074 (Human); 17113 (Mouse); 312689 (Rat)

Alternate Names

000 Man6PR; 46 kDa mannose 6-phosphate receptor; 46-kDa mannose 6-phosphate receptor; cation-dependent mannose-6-phosphate receptor; CD Man-6-P receptor; CDM6PR; CD-M6PR; CD-MPR; FLJ32994; M6PR; mannose-6-phosphate receptor (cation dependent); MPR 46; MPR46; MPRD; Mr 46; SMPR