Human CD27 Ligand/TNFSF7 (NP_001243) VersaClone cDNA

Human CD27 Ligand/TNFSF7 (NP_001243) VersaClone cDNA Summary

Specifications

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Background: CD27 Ligand/TNFSF7

CD27 Ligand, also known as CD70 and TNFSF7, is a type II transmembrane glycoprotein belonging to the TNF superfamily (TNFSF). CD27 Ligand expression is induced by antigen-receptor activation in B cells. CD27/TNFRSF7 is expressed on natural killer (NK) cells and subsets of T and B cells. CD27 ligation on NK cells induces proliferation and IFN production. CD27 ligation on T cells provides a co-stimulatory signal required for T cell proliferation, clonal expansion and the promotion of effector T cell formation. CD27 ligation on B cells inhibits terminal differentiation of activated B cells into plasma cells and enhances commitment to memory B cell responses.

Related Research Areas

• B Cell Development and Differentiation
• Co-stimulatory and Co-inhibitory Molecules
• gamma delta T Cells
• Regulation of Apoptosis by TNF Superfamily Members
• Regulation of B Cell Activation and Homeostasis by TNF Superfamily Members
• Regulation of Natural Killer Cell Co-stimulation by TNF Superfamily Members
• Regulation of T Cell Co-stimulation by TNF Superfamily Members
• Regulatory T Cells (Tregs)
• Search Cytokine and Growth Factor Products
• Search Immune Checkpoint Targets
• TNF Superfamily
• TNF Superfamily Ligands