Human CD4 Antibody

Name: Human CD4 Antibody
Brand: R&D Systems
SKU: MAB3791
Rating: 4 (1 reviews)

Catalog #: MAB3791
2 Citations 1 Review Datasheet / COA / SDS

Newer Version Available: MAB11426

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Discontinued Product

MAB3791 has been discontinued and is replaced by MAB11426.

All CD4 Antibodies

Product Details

Citations (2)

FAQs

Reviews (1)

Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human CD4 Antibody Summary

Species Reactivity

Human

Specificity

Detects human CD4 in direct ELISAs and Western blots. Does not cross-react with recombinant mouse CD4.

Source

Monoclonal Mouse IgG_2A Clone # 34915

Purification

Protein A or G purified from ascites

Immunogen

Recombinant human CD4
Extracellular domain
Accession # P01730

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Applications

Recommended Concentration

Sample

Western Blot

1 µg/mL

Recombinant Human CD4 (Catalog # 514-CD)

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Reconstitution

Reconstitute at 0.5 mg/mL in sterile PBS.

Shipping

Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: CD4

CD4 is a type I membrane glycoprotein belonging to the immunoglobulin superfamily. It is expressed predominantly on thymocytes and a subset of mature T lymphocytes. CD4 functions in collaboration with the T cell receptor in the recognition of peptide antigens that are presented by class II major histocompatibility complexes. CD4 also has been shown to be a coreceptor of HIV entry and specifically binds gp120, the external envelope glycoprotein of HIV.

Entrez Gene IDs

920 (Human); 12504 (Mouse); 24932 (Rat); 403931 (Canine); 101864991 (Cynomolgus Monkey); 493775 (Feline)

Alternate Names

CD_antigen: CD4; CD4 antigen (p55); CD4 antigen; CD4 molecule; CD4 receptor; CD4; CD4mut; T-cell surface antigen T4/Leu-3; T-cell surface glycoprotein CD4

Product Datasheets

Product Datasheet

COA

SDS

Related Research Areas

Citations for Human CD4 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

2 Citations: Showing 1 - 2
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Retroviral infection of human neurospheres and use of stem Cell EVs to repair cellular damage
Authors: H Branscome, P Khatkar, S Al Sharif, D Yin, S Jacob, M Cowen, Y Kim, J Erickson, CA Brantner, N El-Hage, LA Liotta, F Kashanchi
Scientific Reports, 2022-02-07;12(1):2019.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot
Protein kinase C and NF-kappaB-dependent CD4 downregulation in macrophages induced by T cell-derived soluble factors: consequences for HIV-1 infection.
Authors: Raposo RA, Trudgian DC, Thomas B, van Wilgenburg B, Cowley SA, James W
J. Immunol., 2011-06-10;187(2):748-59.
Species: Human
Sample Types: Cell Culture Supernates
Applications: Western Blot