Human CD47 (NP_001768) VersaClone cDNA

Human CD47 (NP_001768) VersaClone cDNA Summary

Specifications

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Background: CD47

CD47, also known as Integrin-Associated Protein (IAP) and OA3, is a ubiquitous transmembrane protein that binds to SIRP family members on macrophages, neutrophils, and T cells. These interactions prevent macrophage-mediated clearance of healthy CD47-expressing cells and promote immune cell transmigration across the vascular endothelium. CD47 associates in cis with Fas on T cells and enhances Fas-mediated apoptosis; its ligation promotes T cell anergy and dampens Th1 immune responses. CD47 also associates in cis with several Integrins?which can positively or negatively modulate Integrin-mediated function. CD47 binding by Thrombospondin-1 inhibits the angiogenic and vasorelaxant effects of nitric oxide. On dendritic cells and myeloma cells, CD47 ligation by TSP-1 induces giant cell formation and osteoclast differentiation.

Related Research Areas

• Acute Myeloid Leukemia
• Adhesion Molecules in Angiogenesis
• Adhesion Molecules on VSMC
• Cancer Stem Cell Markers
• Dendritic Cell Pathogen Recognition/Uptake
• Immune Regulatory Molecules on Endothelial Cells
• Immunoglobulin Superfamily CAMs
• Integrins and Associated Molecules
• Lymphoma
• Microglia Activation
• Microglia Homeostasis
• Search Immune Checkpoint Targets
• Uptake of Amyloid beta by Glia Cells