Human CEACAM-18 Antibody Summary
Gln31-His317
Accession # A8MTB9
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
View Larger
Detection of CEACAM-18 in HEK293 cells by Flow Cytometry. HEK293 cells transfected with Human CEACAM-18 (A) vs Irrelevant transfectant cells (B) were stained with Mouse Anti-Human CEACAM-18 Monoclonal Antibody (Catalog # MAB9869, filled histogram), followed by Phycoerythrin-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # F0102B). View our protocol for Staining Membrane-associated Proteins.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: CEACAM-18
Carcinoembryonic Antigen-related Cell Adhesion Molecule 18 (CEACAM-18) is part of the CEA protein family consisting of CEACAMs and the pregnancy-specific glycoproteins (PSGs). Both CEACAM and PSG molecules have been identified in humans and belong to the much larger glycosylphosphatidylinositol (GPI)-linked immunoglobulin (Ig) superfamily (1, 2). Mature human CEACAM-18 has a 298 amino acid (aa) extracellular domain containing 2 IgC2-like and 1 IgV-like domains, a single transmembrane domain and a short cytoplasmic tail (2). CEACAM-18 is one of only five conserved CEACAMs among mouse, rat, and human (2), but mature human CEACAM-18 has low aa sequence identify with mouse and rat at 60% and 58%, respectively. Originally discovered as a biomarker for colorectal cancer (3), CEACAMs have now been associated with numerous intracellular signaling processes including cell adhesion, cell growth, recognition and differentiation, angiogenesis, and apoptosis (4-6). While the exact function of CEACAM-18 has been yet to be elucidated, it may bind pathogen receptors or other immunoregulatory members (6). CEACAM family members were identified as the major Galectin-3 receptor candidates on human neutrophils (7). Binding of carbohydrate ligands to CEACAMs may be important in the release of proinflammatory mediators (8, 9).
- Beauchemin, N. et al. (1999) Exp. Cell Res. 252:243.
- Zebhauser, R. et al. (2005) Genomics 86:566.
- Gold, P and Freedman SO, 1965) J Exp Med 122:467.
- Obrink, B. (1997) Curr Opin Cell Biol 9:616.
- Horst, A.K. and Wagener, C. (2004) Handb Exp Pharmacol 283.
- Kuespert, K. et al. (2006) Curr Opin Cell Biol. 18(5):565.
- Feuk-Lagerstedt, E. et al. (1999) J. Immunol. 163:5592.
- Yoon, J. et al. (2007) J. Immunol. 179:8454.
- Schröder, A.K. et al. (2006) Hum Immunol. 67:676.
Product Datasheets
FAQs
No product specific FAQs exist for this product, however you may
View all Antibody FAQsReviews for Human CEACAM-18 Antibody
There are currently no reviews for this product. Be the first to review Human CEACAM-18 Antibody and earn rewards!
Have you used Human CEACAM-18 Antibody?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
