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Human ChemR23 Antibody

Catalog #: MAB362
8 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
MAB362
MAB362-SP
Product Details
Citations (8)
FAQs
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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human ChemR23 Antibody Summary

Species Reactivity
Human
Specificity
Detects human ChemR23. Stains human ChemR23-transfected cells but not irrelevant transfectants.
Source
Monoclonal Mouse IgG3 Clone # 84939
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
NS0 mouse myeloma cell line transfected with human ChemR23
Met1-Leu371
Accession # NP_004063
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Flow Cytometry
2.5 µg/106 cells
Human peripheral blood monocytes
CyTOF-ready
Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation.
 

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS.
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Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: ChemR23

ChemR23 is a chemoattractant receptor expressed on dendritic cells and activated macrophages. ChemR23 binds Chemerin and functions as a coreceptor for SIV and some primary HIV-1 strains.

References
  1. Samson, M. et al. (1998) Eur. J. Immunol. 28:1689.
Long Name
Chemokine-like Receptor 1/Orphan G Protein-coupled Receptor ChemR23
Entrez Gene IDs
1240 (Human); 14747 (Mouse); 60669 (Rat)
Alternate Names
CHEMERINR; chemokine receptor-like 1; chemokine-like receptor 1; ChemR23; cmklr1; Dez; Gpcr27; G-protein coupled receptor ChemR23; G-protein coupled receptor DEZ; MGC126105; MGC126106; orphan G-protein coupled receptor, Dez

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Citations for Human ChemR23 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

8 Citations: Showing 1 - 8
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  1. ChemR23, the receptor for chemerin and resolvin E1, is expressed and functional on M1 but not on M2 macrophages.
    Authors: Herova M, Schmid M, Gemperle C, Hersberger M
    J Immunol, 2015-01-30;194(5):2330-7.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  2. Chemerin C9 peptide induces receptor internalization through a clathrin-independent pathway.
    Authors: Zhou J, Liao D, Zhang S, Cheng N, He H, Ye R
    Acta Pharmacol Sin, 2014-03-24;35(5):653-63.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  3. Resolvin E1 and chemokine-like receptor 1 mediate bone preservation.
    Authors: Gao L, Faibish D, Fredman G, Herrera B, Chiang N, Serhan C, Van Dyke T, Gyurko R
    J Immunol, 2012-12-14;190(2):689-94.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow Cytometry, ICC
  4. Potential role of chemerin in recruitment of plasmacytoid dendritic cells to diseased skin.
    Authors: Skrzeczynska-Moncznik J, Wawro K, Stefanska A, Oleszycka E, Kulig P, Zabel BA, Sulkowski M, Kapinska-Mrowiecka M, Czubak-Macugowska M, Butcher EC, Cichy J
    Biochem. Biophys. Res. Commun., 2009-01-23;380(2):323-7.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  5. Characterization of the human chemerin receptor--ChemR23/CMKLR1--as co-receptor for human and simian immunodeficiency virus infection, and identification of virus-binding receptor domains.
    Authors: Martensson UE, Fenyo EM, Olde B, Owman C
    Virology, 2006-08-10;355(1):6-17.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  6. Consequences of ChemR23 Heteromerization with the Chemokine Receptors CXCR4 and CCR7
    Authors: Cédric de Poorter, Kevin Baertsoen, Vincent Lannoy, Marc Parmentier, Jean-Yves Springael
    PLoS ONE
  7. Human articular chondrocytes express ChemR23 and chemerin; ChemR23 promotes inflammatory signalling upon binding the ligand chemerin(21-157)
    Authors: Vivian Berg, Baldur Sveinbjörnsson, Signy Bendiksen, Jan Brox, Khaled Meknas, Yngve Figenschau
    Arthritis Research & Therapy
  8. Chemerin15 inhibits neutrophil‐mediated vascular inflammation and myocardial ischemia‐reperfusion injury through ChemR23
    Authors: Jenna L Cash, Stefania Bena, Sarah E Headland, Simon McArthur, Vincenzo Brancaleone, Mauro Perretti
    EMBO reports

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