Human ChemR23 APC-conjugated Antibody Summary
Met1-Leu371
Accession # NP_004063
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of ChemR23 in Human Whole Blood Monocytes by Flow Cytometry. Human whole blood monocytes were stained with Mouse Anti-Human IL-3 R alpha/CD123 PE-conjugated Monoclonal Antibody (FAB301P) and either (A) Mouse Anti-Human ChemR23 APC-conjugated Monoclonal Antibody (Catalog # FAB362A) or (B) Mouse IgG3Allophycocyanin Isotype Control (IC007A). View our protocol for Staining Membrane-associated Proteins.
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Detection of ChemR23 in HEK293 Human Cell Line Transfected with Human ChemR23 and eGFP by Flow Cytometry. HEK293 human cell line (A) transfected with human ChemR23 or (B) irrelevant protein and eGFP, were stained with Mouse Anti-Human ChemR23 APC-conjugated Monoclonal Antibody (Catalog # FAB362A). Quadrant markers were set based on Mouse IgG3Allophycocyanin Isotype Control (IC007A, data not shown). Staining was performed using our Staining Membrane-associated Proteins protocol.
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Preparation and Storage
Background: ChemR23
ChemR23, also known as CMKLR1, is a 47-48 kDa 7-transmembrane member of the rhodopsin, or G-protein coupled receptor family 1. It has restricted expression on select cell types that, in primate, include adipocytes, astrocytes, endothelial cells, microglia/macrophages, chondrocytes, monocytes, osteocytes, NK cells, and plasmacytoid plus myeloid dendritic cells. In mouse, would studies show ChemR23 to be expressed by neutrophils and keratinocytes. The universally-agreed on ligand for ChemR23 is Chemerin, a 137 amino acid (aa) non-chemokine product of fibroblasts, platelets, adipocytes and endothelium. The Chermerin:ChemR23 system is suggested to promote chemotaxis for all ChemR23+ cells, and to induce angiogenesis via endothelial cell migration and MMP-2 and -9 activation. There is one alternative splice form that shows a deletion of aa 1 and 2 (NP_004063). Over the extracellular domains of ChemR23, human and mouse share 69% aa sequence identity.
Product Datasheets
Citations for Human ChemR23 APC-conjugated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Pro-Resolving Mediators in Rotator Cuff Disease: How Is the Bursa Involved?
Authors: Klatte-Schulz, F;Bormann, N;Bonell, A;Al-Michref, J;Nguyen, HL;Klöckner, P;Thiele, K;Moroder, P;Seifert, M;Sawitzki, B;Wildemann, B;Duda, GN;
Cells
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Mesenchymal stromal cell-secreted chemerin is a novel immunomodulatory molecule driving the migration of ChemR23-expressing cells
Authors: Paola Vinci
Cytotherapy, 2016-12-06;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
ChemR23, the receptor for chemerin and resolvin E1, is expressed and functional on M1 but not on M2 macrophages.
Authors: Herova M, Schmid M, Gemperle C, Hersberger M
J Immunol, 2015-01-30;194(5):2330-7.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry
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