Human Complement Component C1rLP Antibody

Catalog #: AF3676 Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
AF3676
AF3676-SP

All Complement Component C1rLP Antibodies

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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human Complement Component C1rLP Antibody Summary

Species Reactivity

Human

Specificity

Detects human Complement Component C1rLP in direct ELISAs and Western blots. In direct ELISAs and Western blots, approximately 10% cross-reactivity with recombinant mouse C1rLP is observed and less than 5% cross-reactivity with recombinant human (rh) C1R, rhC1S, and rhMASP-3 is observed.

Source

Polyclonal Goat IgG

Purification

Antigen Affinity-purified

Immunogen

Mouse myeloma cell line NS0-derived recombinant human Complement Component C1rLP
Ser41-Asn487
Accession # AAI56781

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Applications

Recommended Concentration

Sample

Western Blot

0.1 µg/mL

Recombinant Human Complement Component C1rLP

Immunoprecipitation

25 µg/mL

Conditioned cell culture medium spiked with Recombinant Human Complement Component C1rLP, see our available Western blot detection antibodies

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Reconstitution

Reconstitute at 0.2 mg/mL in sterile PBS.

Shipping

Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Complement Component C1rLP

C1rLP, also known as CLSPa, is a plasma serine protease that is related to the C1r complement component. C1rLP is a 487 amino acid protein that contains one CUB domain and a serine protease domain. C1rLP activates pro-C1s and pro-haptoglobin but also inhibits complement-mediated cytotoxicity. Human and mouse C1rLP share 73% aa sequence identity.

Long Name

Complement C1r Subcomponent-like Protein

Entrez Gene IDs

51279 (Human); 232371 (Mouse)

Alternate Names

C1RL; C1RL1; C1RL1complement C1r subcomponent-like protein; C1r-like protein; C1r-like serine protease analog protein; C1r-LPcomplement C1r-like proteinase; C1RLPEC 3.4.21.-; CLSPa; complement component 1, r subcomponent-like; Complement Component C1rLP; EC 3.4.21; EC 3.4.21.41